1300-73-8

Xylidines are used in dyestuff manufacture; as intermediates in the manufacture of pesticides, antioxidants, pharmaceuticals, and other organic com pounds.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

UN1711/Xylidines, solid or liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Vapor may form explosive mixture with air. Contact with hypo chlorite salts and bleaches form explosive chloroamines. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. A chemical base: Will neutralize acids to form salts plus water with an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides.

There are six xylidine isomers. Xylidine,mixed isomers (principally made up of 2,4-, 2,5-, and 2,6-isomers), is a pale yellow to brown liquid with a weak,aromatic amine odor. The odor threshold is 0.056 ppm.Molecular weight=121.20; Specific gravity (H2O:1) =0.98 at 25℃; Boiling point (mixed isomers) =213-226℃;Freezing/Melting point=236℃; Vapor pressure =<1 mmHg at 25℃; Flash point (2,6-isomer)= 91℃;(mixed isomers) 96.7℃. Explosive limits (2,6-isomer):LEL =1.0%; UEL—unknown. Hazard Identification (basedon NFPA-704 M Rating System): Health 3, Flammability 1,Reactivity 0. Insoluble in water.

Liquid. Slightly soluble inwater; soluble in alcohol and ether. Combustible.

There are six xylidine isomers. Xylidine, mixed isomers (principally made up of 2,4-, 2,5-, and 2,6-isomers) is a pale yellow to brown liquid with a weak, aromatic amine odor.

Incineration; oxides of nitrogen are removed from the effluent gas by scrubber, catalytic, or thermal device.

Chemical intermediate in the manufacture of pesticides, dyes, antioxidants, pharmaceuticals, synthetic resins, and fragrances.

Chiefly in the manufacture of dyes.

Toxic by ingestion, inhalation, and skin absorption. Liver damage. Methemoglobinemia. Possible carcinogen.

Xylidine causes liver damage in experimental animals and is a mild methemoglobin former; it caused tumors of the nasal cavity in rats. There are six isomeric forms of xylidenes with the commercial product consisting primarily of the 2,4- and 2,6-isomers.

The IARC has determined that there is sufficient evidence for the carcinogenicity of 2,6-xylidine in experimental animals and inadequate evidence in humans.5 Overall, 2,6- xylidine is considered possibly carcinogenic to humans. In genotoxic assays, 2,6-xylidine induced sister chromatid exchanges and chromosomal aberrations in cultured mammalian cells but did not induce micronuclei in the bone marrow of mice treated in vivo; conflicting results have been reported in the Salmonella typhimurium assay.

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Before entering confined space where this chemicalmay be present, check to make sure that an explosiveconcentration does not exist. Xylidine must be stored toavoid contact with strong oxidizers (such as bromine,chlorine, or fluorine) since violent reactions occur. Contactwith hypochlorite bleaches may form explosive chloroamines. Store in tightly closed containers in a cool, dry,well-ventilated area away from heat sources. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard. Metalcontainers involving the transfer of 5 gallons or more ofthis chemical should be grounded and bonded. Drums mustbe equipped with self-closing valves, pressure vacuumbungs, and flame arresters. Use only nonsparking tools andequipment, especially when opening and closing containersof this chemical. A regulated, marked area should beestablished where this chemical is handled, used, or storedin compliance with OSHA Standard 1910.1045.