General Description
Clear colorless liquid.
Reactivity Profile
LINOLENIC ACID(463-40-1) is incompatible with bases, oxidizing agents and reducing agents. Also incompatible with peroxides, oxygen and water.
Air & Water Reactions
Oxidizes in air to form peroxides, which spontaneously ignite. Insoluble in water. Sensitive to heat and moisture.
Fire Hazard
This chemical is probably combustible.
Chemical Properties
clear light yellow to yellow liquid
Occurrence
linolenic acid occurs as the glyceride in many seed fats. It is an essential fatty acid in the diet.
Definition
A liquid unsaturated carboxylic
acid that occurs in LINSEED OIL and
other plant oils. It contains three double
bonds.
Definition
ChEBI: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.
Definition
linolenic acid: A liquid polyunsaturatedfatty acid with three doublebonds in its structure:CH3CH2CH:CHCH2CH:CHCH2CH:CH-(CH2)7COOH. It occurs in certainplant oils, e.g. linseed and soya-beanoil, and in algae. It is one of the essentialfatty acids.
Biochem/physiol Actions
An ω-3 fatty acid that serves as a precursor to eicosapentaenoic acid (EPA) but not docosahexaenoic acid. Conversion is greater in women than men, and conversely, β-oxidation metabolism is greater in men than women.
Carcinogenicity
Narisawa et al. found that
diets high in perilla oil (with high a-linolenic acid but also
high levels of linoleic acid) lowered the risk of colon cancer
in a rat model initiated with the carcinogen N-methyl-Nnitrosourea.
Okuno found a suppressive effect on diethylnitrosamine-
induced heptaocarcinogenesis in male Fischer
344 rats treated with either safflower (high in linoleic
acid) or perilla oil (high in both linoleic and α-linolenic
acids). Kitano et al. found that 10% α-linolenic
acid did not promote urninary bladder cancer initiated in rats
with N-butyl-N-(4-hydrocybutyl)nitrosamine. Mice fed
a-linolenic acid at 5–10% of the diet had increased mammary
gland ductular cell proliferation.