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2-Methyl-5-nitrobenzenesulfonamide is a chemical reagent in the synthesis of good inhibitors of cancer-related carbonic anhydrase. Also used in the synthesis of novel deacetylase inhibitors used in anti-tumor therapy.

In the 2-Methyl-5-nitrobenzenesulfonamide, C7H8N2O4S, the nitro group is twisted by 9.61 (2)° relative to the benzene ring. In the crystal, mol-ecules are linked by N—H…O and N—H…(O, O) hydrogen bonds between the amino and sulfonyl groups, forming layers parallel to (001)[1].

[1] Muhammad Zia-Ur-Rehman. “2-Methyl-5-nitro-benzene-sulfonamide.” Acta crystallographica. Section E, Structure reports online 66 Pt 1 (2009): o136.