黄素腺嘌呤二核苷酸

简介生物活性靶点体外研究体内研究黄素腺嘌呤二核苷酸试剂级价格

黄素腺嘌呤二核苷酸

CAS号:146-14-5
英文名:FLAVIN ADENINE DINUCLEOTIDE
中文名:黄素腺嘌呤二核苷酸
CBNumber:CB0294159
分子式:C27H33N9O15P2
分子量:785.55
MOL File:146-14-5.mol

黄素腺嘌呤二核苷酸化学性质

密度 :2.08±0.1 g/cm3(Predicted)
储存条件 :−20°C
溶解度 :Methanol (Slightly, Heated), Water (Slightly)
形态 :powder
酸度系数(pKa) :1.13±0.50(Predicted)
颜色 :orange
Merck :4091
稳定性 :Stable. Incompatible with strong oxidizing agents.
CAS 数据库 :146-14-5
EPA化学物质信息 :Riboflavin 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with adenosine (146-14-5)

安全信息

安全说明 :24/25
WGK Germany :3
RTECS号 :AU7470000
F :8-10-21
海关编码 :29349990

黄素腺嘌呤二核苷酸性质、用途与生产工艺

简介
黄素腺嘌呤二核苷酸（英语：FAD），又称活性型维生素B2、核黄素-5'-腺苷二磷酸，是一种参与了重要的代谢反应的氧化还原辅酶。FAD是一种比NAD和NADP更强的氧化剂，能被1个电子或2个电子途径还原。其可用于标记黄嘌呤腺嘌呤氧化酶，核黄素激酶肿瘤坏死因子受体1 NADPH氧化酶。
生物活性 Flavin adenine dinucleotide (FAD) 是一种氧化还原辅因子，蛋白质的辅基，在代谢过程中参与了几个重要的酶反应。
靶点

Human Endogenous Metabolite
体外研究

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 ^-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.
体内研究

Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.
化学性质橙黄色粉末，有吸湿性，易溶于水，不溶于乙醇，水溶液呈黄绿色荧光，遇碱分解为核黄素。
用途适用于皮肤黏膜疾患、神经性耳鸣、脑动脉硬化、顽固性头痛、肝硬化、黄疸及其他肝病、眼疾、视网膜疾患。静注过快可见暂性胸部不适。