α-倒捻子素

概述生物活性靶点体外研究体内研究 α-倒捻子素试剂级价格

α-倒捻子素

CAS号:6147-11-1
英文名:Mangostin
中文名:α-倒捻子素
CBNumber:CB0739500
分子式:C24H26O6
分子量:410.46
MOL File:6147-11-1.mol

α-倒捻子素化学性质

熔点 :180-182°C
沸点 :640.1±55.0 °C(Predicted)
密度 :1.265±0.06 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :methanol: soluble1mg/mL, clear, very light yellow
形态 :powder
酸度系数(pKa) :7.22±0.20(Predicted)
颜色 :faint yellow to yellow
最大波长(λmax) :346nm(MeOH)(lit.)
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey :GNRIZKKCNOBBMO-UHFFFAOYSA-N
SMILES :C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
CAS 数据库 :6147-11-1(CAS DataBase Reference)

安全信息

危险品标志 :T
危险类别码 :25
安全说明 :45
危险品运输编号 :UN 2811 6.1 / PGIII
WGK Germany :1
RTECS号 :ZD6122420
海关编码 :29329990
毒害物质数据 :6147-11-1(Hazardous Substances Data)

α-倒捻子素性质、用途与生产工艺

概述 α-倒捻子素是从植物山竹子中提取的一种氧杂蒽酮类化合物。此外，α-倒捻子素来源于天然山竹子的有效成分，具有安全无毒及悠久食用历史等特点，对α-倒捻子素作为药物的深入研究提供了理论和应用基础。
生物活性 alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮，如抗氧化剂，抗过敏，抗病毒，抗菌，抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂，Ki值为 2.85 μM。
靶点

IC50: 2.85 μM (IDH1-R132H)
体外研究

alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H ₂ O ₂ -induced apoptosis of RPE cells. 200 μM H ₂ O ₂ -induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).
体内研究

alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于藤黄科(Guttiferae)山竹壳、罗汉果、山竺。
用途 α-倒捻子素具有治疗腹泻、疟疾、抗炎、抗溃疡以及抗白血病和败血病的作用。
用途用于含量测定/鉴定/药理实验等
药理药效:具有抗氧化、抗炎、抗菌、抗癌等药理活性