小豆蔻明

理化性质生物活性靶点体外研究体内研究小豆蔻明试剂级价格

小豆蔻明

CAS号:19309-14-9
英文名:CARDAMONIN
中文名:小豆蔻明
CBNumber:CB31092214
分子式:C16H14O4
分子量:270.28
MOL File:19309-14-9.mol

小豆蔻明化学性质

熔点 :199～200℃
沸点 :484.5±45.0 °C(Predicted)
密度 :1.282±0.06 g/cm3(Predicted)
储存条件 :room temp
溶解度 :DMSO: ≥20mg/mL
酸度系数(pKa) :7.00±0.40(Predicted)
形态 :powder
颜色 :yellow
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.

安全信息

危险品标志 :N
危险类别码 :50/53
安全说明 :61-24/25
危险品运输编号 :UN 3077 9 / PGIII
海关编码 :29242990

小豆蔻明性质、用途与生产工艺

理化性质小豆蔻明(Cardamonin)，为黄色针晶，易溶于甲醇、乙醇、醋酸乙酯，乙醚，稀碱溶液，难溶于水，与醋酸铅反应呈黄色沉淀。小豆蔻明可以明显抑制络氨酸酶的活性，同时可以有效抑制黑色素细胞增殖和黑色素的合成，效果明显超过其他成分。
生物活性 (E)-Cardamonin ((E)-Cardamomin) 是新颖的hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
靶点
Target Value
NF-κB
(Cell-free assay)
TRPA1
(Cell-free assay) 454 nM
体外研究

(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC ₅₀ =454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
体内研究

(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
化学性质黄色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于草豆蔻。
用途小豆蔻明具有抗菌、止呕、健脾的作用。
用途用于含量测定/鉴定/药理实验等