化学性质 五味子药材的总木脂素含量测定 生物活性 靶点 体外研究 体内研究 五味子酯甲 试剂级价格
ChemicalBook  CAS数据库列表  五味子酯甲

五味子酯甲

五味子酯甲,58546-56-8,结构式
五味子酯甲
  • CAS号:58546-56-8
  • 英文名:Schisantherin A
  • 中文名:五味子酯甲
  • CBNumber:CB5462083
  • 分子式:C30H32O9
  • 分子量:536.57
  • MOL File:58546-56-8.mol
五味子酯甲化学性质
  • 熔点 :110~112℃
  • 沸点 :675.6±55.0 °C(Predicted)
  • 密度 :1.33±0.1 g/cm3(Predicted)
  • 储存条件 :Inert atmosphere,Store in freezer, under -20°C
  • 溶解度 :Chloroform (Slightly), Methanol (Slightly, Sonicated)
  • 形态 :Solid
  • 酸度系数(pKa) :13.70±0.60(Predicted)
  • 颜色 :White to Off-White
  • 水溶解性 :insoluble in water
安全信息
  • 安全说明 :24/25
  • 海关编码 :29329990

五味子酯甲性质、用途与生产工艺

  • 化学性质 长方形结晶 (乙醇),mp 122℃~124℃,[α]D23 -175°(c=0.12,氯仿)。易溶于苯、氯仿、丙酮,可溶于甲醇、乙醇,难溶于石油醚,不溶于水。
    五味子果仁的乙醇提取物中分离得到去氧五味子素、五味子素、五味子乙素、五味子丙素、五味子醇乙、五味子酯甲和五味子酯乙等7个有降转氨酶活性的联苯环辛烯类木脂素。七种成份都有降低SGPT、促进肝糖元生成和延长戊巴比妥睡眠时间的作用。五味子酯乙降SGPT作用最强,五味子醇乙促进肝糖元生成作用最显著,五味子丙素延长戊巴比妥睡眠时间作用最突出。
  • 五味子药材的总木脂素含量测定 五味子为木兰科植物五味子Schisandra chinensis (Turcz.) Baill. 的干燥成熟果实。主要含有木脂素类、挥发油类、多糖类等成分。
    南五味子中木脂素类成分主要有五味子酯甲、乙、丙、丁、戊和去氧五味子素。主要是五味子酯甲,含量较高。木脂素成分除五味子酯戊外,结构式在B环上都有亚甲二氧基,都可与变色酸反应。所以用五味子酯甲为对照,测得的结果基本上反映了南五味子中总木脂素的含量。
    (1) 对照品溶液的配制:取五味子酯甲对照品适量,精密称定,用甲醇配制成5mg/ml的溶液即得。
    (2) 样品溶液的制备:取华中五味子 (南五味子) 果实粉末约1g,精密称定。置具塞瓶中,精密加入甲醇20ml,超声处理20min,放冷至室温,摇匀,过滤,弃去初滤液,取续滤液即得。
    (3) 测定:精密吸取对照品溶液20μl,供试品溶液20μl,甲醇20μl分别置具塞试管中,水浴挥去甲醇,在三个残留物中分别各精密加入10%变色酸澄清水溶液0.5ml,浓硫酸3.0ml,蒸馏水1.5ml,摇匀,同置沸水浴中加热30min,迅速冷却,以上述甲醇管为空白,照分光光度法,在570nm波长处分别测定吸收度,计算即得。
    (4) 测定结果:对不同产地的南五味子药材,按所拟定的方法操作,测得其结果。
  • 生物活性 Schisantherin A (Gomisin C, Schisanwilsonin H, Arisanschinin K)是一种五味子红素,具有止咳、镇静、消炎、抗骨质疏松、神经保护、增强认知和心脏保护活性。Schisantherin A 也可通过IκBα降解抑制p65-NF-κB向核内移位。
  • 靶点
    TargetValue
    NF-κB
    ()
  • 体外研究

    The concentrations of TNF-α and IL-6 in the supernatant of cells pretreated with 2.5 or 25 mg/L of Schisantherin A are significantly decreased compared to the LPS control group (p<0.05, p<0.01). The potential cytotoxicity of Schisantherin A is evaluated by the MTT assay after incubating cells for 24 h in the absence or presence of LPS, result shows cell viabilities are not affected by the cytokines at concentrations used (0.5, 2.5, 25 mg/L). RAW 264.7 murine macrophage cells are pre-incubated with Schisantherin A for 1 h and then stimulated with 1 mg/L LPS for 12 h. Both LPS and samples are untreated in control group. After the cell culture media are collected, nitrite and PGE 2 levels are determined, and Schisantherin A is found to reduce NO and PGE 2 production in a dose-dependent manner.

  • 体内研究

    Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera , has been reported to possess varied beneficial pharmacological effects. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Pretreatment with Schisantherin A markedly ameliorates LPS-induced histopathologic changes and decreases the levels of TNF-α, IL-6 and IL-1β in the BALF. In addition, the phosphorylation of NF-κB p65, IκB-α, JNK, ERK and p38 induced by LPS are suppressed by Schisantherin A. The lung wet/dry weight ratio is evaluated at 7 h after the intranasal instillation of LPS. The results show that there are no differences between control group and Schisantherin A (40 mg/kg) group (p>0.05). LPS causes a significant increase in lung wet/dry weight ratio (p<0.01) compared with the control group. Schisantherin A dose-dependently decreases the lung wet/dry weight ratio (p<0.05) compared to those in the LPS group.

五味子酯甲上下游产品信息
上游原料
下游产品
五味子酯甲 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-N0694
  • 产品名称:Schisantherin A
  • CAS编号:
  • 包装:5 mg
  • 价格:530元
  • 更新日期:2024/01/25
  • 产品编号:HY-N0694
  • 产品名称:五味子酯甲 Schisantherin A
  • CAS编号:58546-56-8
  • 包装:10mM * 1mLin DMSO
  • 价格:626元
五味子酯甲生产厂家
  • 公司名称:化夏化学
  • 联系电话:400-1166-196 18981987031
  • 电子邮件:cdhxsj@163.com
  • 国家:中国
  • 产品数:11726
  • 优势度:57
  • 公司名称:艾科试剂
  • 联系电话:4008-755-333 18080918076
  • 电子邮件:800078821@qq.com
  • 国家:中国
  • 产品数:9725
  • 优势度:55
58546-56-8, 五味子酯甲相关搜索: