生物活性 靶点 体外研究 体内研究 紫铆因 试剂级价格
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紫铆因

紫铆因,487-52-5,结构式
紫铆因
  • CAS号:487-52-5
  • 英文名:BUTEIN
  • 中文名:紫铆因
  • CBNumber:CB8136455
  • 分子式:C15H12O5
  • 分子量:272.25
  • MOL File:487-52-5.mol
紫铆因化学性质
  • 熔点 :216°C
  • 沸点 :560.9±50.0 °C(Predicted)
  • 密度 :1.483±0.06 g/cm3(Predicted)
  • 储存条件 :2-8°C
  • 溶解度 :DMSO: >50 mg/mL
  • 形态 :solid
  • 酸度系数(pKa) :7.44±0.35(Predicted)
  • 颜色 :yellow
  • LogP :2.405 (est)
  • CAS 数据库 :487-52-5(CAS DataBase Reference)
安全信息
  • 安全说明 :22-24/25
  • WGK Germany :3
  • 海关编码 :29145090

紫铆因性质、用途与生产工艺

  • 生物活性 Butein,可从 Dalbergia odorifera T. Chen 分离,是一种 cAMP 特异性的 PDE 抑制剂,对 PDE4 的 IC50为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂,对 EGFR 和 p60c-src 的 IC50 分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路,靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种 SIRT1 激活剂 (STAC)。
  • 靶点

    EGFR

    16 μM (IC 50 , in HepG2 cells)

    PDE4

    10.4 μM (IC 50 )

  • 体外研究

    Butein potently inhibits cAMP-specific phosphodiesterase (type IV) activity with an IC 50 of 10.4±0.4 μM. In contrast, phosphodiesterase I, III and V activities were inhibited by Butein above 100 μM.
    Butein, a plant polyphenol, is a specific protein tyrosine kinase inhibitor. Butein inhibits not only the EGF-stimulated auto-phosphotyrosine level of EGFR in HepG2 cells but also tyrosine-specific protein kinase activities of EGFR (IC 50 =16 μM) and p60 c-src (IC 50 =65 μM) in vitro.
    Butein (10, 20, and 40 μM; 24, 48, and 72 hours) inhibits cell growth in a dose- and time-dependent manner.
    Butein exhibits anticancer activity through the inhibition of the activation of PKB/AKT and MAPK pathways, which are two pathways known to be involved in resistance to cisplatin. Butein (20 µM) decreases phosphorylation of AKT, ERK and p38 following 24 h of co-treatment with Cisplatin (20 µM).

    Cell Viability Assay

    Cell Line: HeLa cells
    Concentration: 10, 20, and 40 μM
    Incubation Time: 24, 48, and 72 hours
    Result: Inhibited cell growth in a dose- and time-dependent manner.

    Western Blot Analysis

    Cell Line: HeLa cells
    Concentration: 20 µM
    Incubation Time: 24 hours
    Result: Decreased phosphorylation of AKT, ERK and p38 co-treatment with Cisplatin (20 µM).
  • 体内研究

    Butein (2 mg/kg every 2 days) in combination with Cisplatin (2 mg/kg every 2 days) for 3 weeks suppresses tumor growth in vivo.

    Animal Model: Nude mice (12 female 6- or 7-week old) with subcutaneous tumor xenografts
    Dosage: 2 mg/kg
    Administration: Intraperitoneally; every 2 days; for 3 weeks
    Result: Enhanced the antitumor effects of Cisplatin in vivo.
  • 用途 

    Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8. Anti-inflammatory agent

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紫铆因 试剂级价格
  • 更新日期:2024/01/16
  • 产品编号:B3803
  • 产品名称:紫铆因 Butein
  • CAS编号:487-52-5
  • 包装:100mg
  • 价格:610元
  • 更新日期:2024/01/16
  • 产品编号:B3803
  • 产品名称:紫铆因 Butein
  • CAS编号:487-52-5
  • 包装:1g
  • 价格:2990元
紫铆因生产厂家
  • 公司名称:北京百灵威科技有限公司
  • 联系电话:010-82848833 400-666-7788
  • 电子邮件:jkinfo@jkchemical.com
  • 国家:中国
  • 产品数:96815
  • 优势度:76
  • 公司名称:BOC Sciences
  • 联系电话:1-631-485-4226; 16314854226
  • 电子邮件:info@bocsci.com
  • 国家:美国
  • 产品数:14059
  • 优势度:65
  • 公司名称:T&W GROUP
  • 联系电话:021-61551611 13296011611
  • 电子邮件:contact@trustwe.com
  • 国家:中国
  • 产品数:9900
  • 优势度:58
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