ChemicalBook > CAS DataBase List > Butorphanol tartrate

Butorphanol tartrate

Product Name:
Butorphanol tartrate
CAS No.
58786-99-5
Chemical Name:
Butorphanol tartrate
CBNumber:
CB0181202
Molecular Formula:
C25H35NO8
Formula Weight:
477.55
MOL File:
58786-99-5.mol
More
Less

Butorphanol tartrate Property

Melting point:
217-219°
alpha 
D22 -64.0° (c = 0.4 in methanol)
storage temp. 
2-8°C
CAS DataBase Reference
58786-99-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-63
Safety Statements 
22-26-36/37/39
RIDADR 
1544
WGK Germany 
3
RTECS 
QC7795000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2933492250
Toxicity
LD50 in mice, rats (mg/kg): 40-57, 17-20 i.v.; 395-527, 570-756 orally (Heel)
More
Less

N-Bromosuccinimide Price More Price(4)

Sigma-Aldrich Gold
Product number:
B9156
Product name :
Butorphanol (+)-tartrate salt
Purity:
≥99%
Packaging:
100mg
Price:
$213
Updated:
2020/08/18
Buy:
Buy
Sigma-Aldrich Gold
Product number:
1082504
Product name :
Butorphanol tartrate
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
350mg
Price:
$551
Updated:
2020/08/18
Buy:
Buy
More
Less

Butorphanol tartrate Chemical Properties,Usage,Production

Uses

Analgesic; antitussive.

Definition

ChEBI: The (S,S)-tartaric acid salt of butorphanol. It is used for relief or moderate to severe pain.

brand name

Stadol (Bristol-Myers Squibb).

Mechanism of action

Butorphanol is a strong agonist at κ opioid receptors, and through this interaction, it is five times more potent than morphine as an analgesic. The κagonists have a lower ceiling analgesic effect than full μ agonists; thus, they are not as effective in treating severe pain. Butorphanol is an antagonist at μ opioid receptors with approximately one-sixth the potency of naloxone. If given to a person addicted to a μ agonist, butorphanol will induce an immediate onset of abstinence syndrome.

Side effects

Butorphanol has a different spectrum of side effects than μ opioid analgesics. Respiratory depression occurs. There is a lower ceiling on this effect, however, and it is not generally lethal, as is the case with high doses of μ agonists. Major side effects after normal analgesic doses are sedation, nausea, and sweating, as well as dysphoric (hallucinogenic) effects at higher doses. Butorphanol causes an increase in pulmonary arterial pressure and pulmonary vascular resistance. There is an overall increased workload on the heart, and it should not be used in patients with congestive heart failure or to treat pain from acute myocardial infarction. Butorphanol has low abuse potential and is not a scheduled drug.

Veterinary Drugs and Treatments

Approved indication for dogs is “. . . for the relief of chronic nonproductive cough associated with tracheobronchitis, tracheitis, tonsillitis, laryngitis and pharyngitis originating from inflammatory conditions of the upper respiratory tract” (Package Insert; Torbutrol?—Fort Dodge). It is also used in practice in both dogs and cats as a preanesthetic medication, analgesic, and as an antiemetic prior to cisplatin treatment (although not very effective in cats for this indication). Compared with other opiate analgesics, butorphanol is not very useful in small animals (particularly dogs) for treating pain and has to be dosed frequently.
The approved indication for horses is “. . . for the relief of pain associated with colic in adult horses and yearlings” (Package Insert; Torbugesic?—Fort Dodge). It has also been used clinically as an analgesic in cattle.

Less

Butorphanol tartrate Suppliers

Global(52)Suppliers
Sinopharm Chemical Reagent Co,Ltd.
Tel:
86-21-63210123
Fax:
86-21-63290778 86-21-63218885
Email:
sj_scrc@sinopharm.com
Country:
China
ProdList:
9848
Advantage:
79
Spectrum Chemical Manufacturing Corp.
Tel:
021-67601398-809
Fax:
021-57711696
Email:
marketing_china@spectrumchemical.com;
Country:
China
ProdList:
9688
Advantage:
60
Shanghai Meishui Chemical Technology Co., Ltd
Tel:
021-60549325 18616193163
Fax:
021-33250306
Email:
mail@meishuichem.com
Country:
China
ProdList:
4537
Advantage:
56
Hangzhou J&H Chemical Co., Ltd.
Tel:
0571-87396432-
Fax:
0571-87396431
Email:
sales@jhechem.com;
Country:
China
ProdList:
13913
Advantage:
53
Sigma-Aldrich
Tel:
021-61415566- ;
Email:
orderCN@merckgroup.com;orderCN@merckgroup.com
Country:
China
ProdList:
34129
Advantage:
80
Chemwill Asia Co.,Ltd.
Tel:
86-21-51086038
Fax:
86-21-51861608
Email:
chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com
Country:
CHINA
ProdList:
23977
Advantage:
58
Chongqing Chemdad Co., Ltd
Tel:
+86-13650506873
Email:
sales@chemdad.com
Country:
CHINA
ProdList:
35434
Advantage:
58
Henan Huawen Chemical Co., Ltd
Tel:
0370-2070108-
Fax:
QQ:2712427897
Email:
2712427897@qq.com
Country:
China
ProdList:
8680
Advantage:
58
CONIER CHEM AND PHARMA LIMITED
Tel:
86-18523575427
Email:
sales@conier.com
Country:
CHINA
ProdList:
47486
Advantage:
58

58786-99-5, Butorphanol tartrateRelated Search:

Gabapentin (1S,2R)-(+)-TRANS-2-PHENYL-1-CYCLOHEXANOL 2-DIMETHYLAMINOETHANOL HYDROGEN L-(+)-TARTRATE Cyclobutylmethylamine Butorphanol tartrate Sodium tartrate D-Tartaric acid BUPRENORPHINE HYDROCHLORIDE 2,2-Bis(hydroxymethyl)propionic acid 2,2-Bis(hydroxymethyl)butyric acid D(-)-Tartaric acid 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT (ethylenedioxy)dimethanol Tylosin tartrate Sodium chloride BUTORPHANOL BUPRENORPHINE L(+)-Tartaric acid
  • MORPHINAN-3,14-DIOL, 17-(CYCLOBUTYLMETHYL)-, (S-(R*,R*))-2,3-DIHYDROXYBUTANEDIOATE (1:1) (SALT)
  • MORPHINAN-3,14-DIOL, 17-(CYCLOBUTYLMETHYL)-,(S-(R,R))-2,3-DIHYDROXYBUTANEDIOATE (1:1) (SALT)
  • morphinan-3,14-diol,17-(cyclobutylmethyl)-,(s-(r*,r*))-2,3-dihydroxybutanedi
  • oate(1:1)(salt)
  • stadol
  • torate
  • torbutrol
  • BUTORPHANOL TARTRATE
  • BUTORPHANOL TARTRATE SALT
  • l-n-cyclobutylmethyl-3,14-dihydroxymorphinan tartrate salt
  • Butorphanol tartrate (jan/usp)
  • D00837
  • Stadol (tn)
  • Butorphanol Tartrate (CIV), USP
  • Butorphanol Tartrate CIV (350 mg)
  • butorphanol D-tartrate
  • 1-N-CYCLOBUTYLMETHYL-3,14-DIHYDROXYMORPHINAN TARTRATE SALT
  • butorphanol tartrate---dea schedule iv
  • 17-(cyclobutylmethyl)morphinan-3,14-diyl [S-(R*,R*)]-2,3-dihydroxysuccinate
  • Morphinan-3,14-diol, 17-(cyclobutylmethyl)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt)
  • BUTORPHANOLTARTRATE,USP
  • l-Butorphanol tartrate
  • Levo-BC 2627 tartrate
  • Moradol
  • NIH 10275
  • Torbugesic
  • 58786-99-5
  • C25H35NO8
  • C21H29NO2C4H6O6
  • 47755