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Daunorubicin

Product Name:
Daunorubicin
CAS No.
20830-81-3
Chemical Name:
Daunorubicin
CBNumber:
CB0338996
Molecular Formula:
C27H29NO10
Formula Weight:
527.52
MOL File:
20830-81-3.mol
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Daunorubicin Property

Melting point:
155 °C
Boiling point:
608.13°C (rough estimate)
Density 
1.3522 (rough estimate)
refractive index 
1.6400 (estimate)
pka
pKa 4.92±0.16(H2O t=25±0.5 I=0.03) (Uncertain)
CAS DataBase Reference
20830-81-3
EPA Substance Registry System
Daunomycin (20830-81-3)
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Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
20830-81-3(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): 20, 13 i.v.; 5, 8 i.p. (DiMarco, 1977)
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Daunorubicin Chemical Properties,Usage,Production

Chemical Properties

Daunomycin is a thin red, needle-shaped material.

Uses

antineoplastic

Uses

Oncology

Uses

Daunorubicin hydrochloride USP (Cerubidine) is used to traet acute lymphocytic and granulocytic leukemia; lymphomas.

Indications

Daunorubicin (Cerubidine) is used to treat acute leukemias, while its structural analogue, doxorubicin (Adriamycin) is extensively employed against a broad spectrum of cancers. Although the two drugs have similar pharmacological and toxicological properties, doxorubicin is more potent against most animal and human tumors and will be discussed in greater detail.

Definition

ChEBI: A natural product found in Actinomadura roseola.

brand name

Cerubidine (Bedford); Cerubidine (Sanofi Aventis); Cerubidine (Wyeth).

General Description

Anthracycline antibiotic. An anticancer agent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human poison by ingestion. Experimental poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also DAUNOMYCIN HYDROCHLORIDE.

Potential Exposure

An antibiotic. It is used as a medicine for treating cancer.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.

Waste Disposal

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quanti- ties of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceuti- cal shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste con- taining this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Daunorubicin Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Daunorubicin Suppliers

Global(116)Suppliers
Shenzhen wanle pharmaceutical co. LTD
Tel:
86-755-2584 3999
Email:
wanle@wanle.com.cn
Country:
CHINA
ProdList:
10
Advantage:
58
Jiangsu raspberry International Trade Co., Ltd.
Email:
2335663646@qq.com
Country:
CHINA
ProdList:
225
Advantage:
58
Shanghai Boyle Chemical Co., Ltd.
Fax:
86-21-57758967
Email:
sales@boylechem.com
Country:
China
ProdList:
2926
Advantage:
55
Taizhou Chemedir Biopharm-tech. Co., Ltd
Tel:
0523-86200218
Fax:
+86 523-86200613
Email:
sale1_cmd@chemedir.com
Country:
China
ProdList:
102
Advantage:
64
LGM Pharma
Tel:
1-(800)-881-8210
Fax:
615-250-9817
Email:
inquiries@lgmpharma.com
Country:
United States
ProdList:
1938
Advantage:
70
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel:
021-51613915- ;021-51613915-822
Fax:
021 51613951
Email:
latika.cui@3wpharm.com;vivian.zhu@3wpharm.com
Country:
China
ProdList:
9879
Advantage:
57
BOC Sciences
Tel:
Email:
info@bocsci.com
Country:
United States
ProdList:
9983
Advantage:
65
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel:
17727448752,0755-83725681-603
Fax:
+86 755 28094224
Email:
rex.liu@phystandard.com;tom.liu@phystandard.com
Country:
China
ProdList:
4508
Advantage:
50
Beijing HuaMeiHuLiBiological Chemical
Tel:
010-56205725;010-86181995
Fax:
010-65763397
Email:
waley188@sohu.com
Country:
China
ProdList:
12341
Advantage:
58

20830-81-3, DaunorubicinRelated Search:

Daunorubicin AMINO ACIDS Adriamycin Erythromycin Acetyl-resveratrol Acetylacetone Doxorubicin hydrochloride Minocycline hydrochloride Gentamicin Clindamycin Glycine 6-Aminocaproic acid Oxytetracycline dihydrate Vancomycin Cephaloridine Tris Base Acetyl coenzyme A sodium salt Azithromycin
  • (8s-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
  • DAUNORUBICIN
  • DAUNORUBICINE HYDROCHLORIDE
  • DAUNOMYCIN
  • DAUNOMYCIN HYDROCHLORIDE
  • LEUKAEMOMYCIN C HYDROCHLORIDE
  • (8s-cis)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyrannosyl)oxy]
  • 3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naph
  • 5,12-naphthacenedione,8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopy
  • -7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione
  • acetyladriamycin
  • cerubidin
  • daunamycin
  • daunarubicinum
  • RP13057;DAUNOMYCIN;RUBIDOMYCIN
  • Daunormycin
  • 5,12-Naphthacenedione, 8-acetyl-10-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
  • 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
  • daunorrubicina
  • daunorubicine
  • daunoxome
  • fi6339
  • leukaemomycinc
  • nci-c04693
  • nsc-82151
  • ranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-tri///
  • rcrawastenumberu059
  • rp13057
  • rubidomycin
  • rubomycinc
  • rubomycinc1
  • thacenyl-3-amino-2,3,6-trideoxy-alpha-l-lyxo
  • 5,12-Naphthacenedione, 8-acetyl-10[(3-amino-2,3,6-trideoxy)-alpha-L-lyxo-hexopyranos) oxyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
  • (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
  • 2,2,6-Trideoxy-3-amino-a-lycszo-4-methoxy-6,7,9,11-tetraoxy-9-aceto-7,8,9,10-tetrahydrotetraacenchynon
  • Zhengdingmycin
  • (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
  • Daunorubicin HCL/Daunomycin
  • Daunorubicin (Daunomycin)
  • Daunorubicin(RP13057)
  • 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
  • 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
  • Daunomycin (8CI)
  • Daunomycine
  • NSC 83142
  • DAUNORUBUCIN
  • 20830-81-3
  • C27H29NO10HClH2O