ChemicalBook CAS DataBase List Calcium gluconate

Calcium gluconate

Product NameCalcium gluconate
CAS299-28-5
CBNumberCB0473578
MFC12H22CaO14
MW430.37
EINECS206-075-8
MDL NumberMFCD00064209
MOL File299-28-5.mol
MSDS FileSDS

Chemical Properties

Melting point	195°C
alpha	10.2 º (c=1, H2O 22 ºC)
Boiling point	400℃[at 101 325 Pa]
Density	1.677[at 20℃]
vapor pressure	0.004Pa at 20℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Sparingly soluble in water, freely soluble in boiling water.
form	Crystals or Crystalline Powder
color	White
PH	pH;6.0～8.0
Odor	at 100.00?%. odorless
Water Solubility	3.3 g/100mL
Hydrolytic Sensitivity	0: forms stable aqueous solutions
Merck	14,1669
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	KYUVBRZSDFBLTH-OSQBQZLYSA-M
LogP	-5.31 at 20℃
CAS DataBase Reference	299-28-5(CAS DataBase Reference)
FDA 21 CFR	184.1199; 582.1199; 582.6199; 310.545
Substances Added to Food (formerly EAFUS)	CALCIUM GLUCONATE
SCOGS (Select Committee on GRAS Substances)	Calcium gluconate
EWG's Food Scores	1
FDA UNII	SQE6VB453K
NCI Dictionary of Cancer Terms	calcium gluconate
NCI Drug Dictionary	calcium gluconate
ATC code	A12AA03,D11AX03
EPA Substance Registry System	D-Gluconic acid, calcium salt (2:1) (299-28-5)

Safety

Symbol(GHS)

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

<ahref="/Hazard-Statements.pdf">P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

RTECS

EW2100000

TSCA

HS Code

29181600

Hazardous Substances Data

299-28-5(Hazardous Substances Data)

Toxicity

dog,LDLo,intravenous,1987mg/kg (1987mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.

NFPA 704:

	1
1		0

Calcium gluconate Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich PHR2669	500MG	$200	Calcium Gluconate Anhydrous Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 500?mg	Buy
Sigma-Aldrich 1086822	200mg	$174.4	Calcium gluconate anhydrous United States Pharmacopeia (USP) Reference Standard	Buy
Sigma-Aldrich C8231	1kg	$311	Calcium D-gluconate anhydrous, meets USP testing specifications (Not intended for use in preparing injectable dosage forms.)	Buy
TCI Chemical G0037	25g	$22	Calcium Gluconate Monohydrate >98.0%(T)	Buy
TCI Chemical G0037	500g	$49	Calcium Gluconate Monohydrate >98.0%(T)	Buy

Calcium gluconate Chemical Properties,Usage,Production

Description

Calcium gluconate is the calcium salt of gluconate, being an oxidative product of glucose containing 9.3% calcium. Calcium gluconate is a kind of mineral supplement and medication. It can be used for vein injection to treat the low blood calcium, high blood potassium, and magnesium toxicity. It is required only when there is not enough calcium in the diet. It is also used for the treatment of black widow spider bites to relieve muscle cramping and treatment of osteoporosis or rickets. It can also be used to decrease the capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses.

References

http://www.drugbank.ca/drugs/DB11126 https://en.wikipedia.org/wiki/Calcium_gluconate

Chemical Properties

white crystalline powder or granules

Uses

Calcium Gluconate is used as an inert ingredient in pesticide formulations applied to crops. It is also used as a supplement to fortify beverages and foods lacking a sufficient amount of calcium.

Uses

In sewage purification; in coffee powders to prevent caking.

Uses

analgesic, antipyretic

Uses

Calcium Gluconate is a white crystalline granule or powder that functions as a firming agent, formulation aid, sequestrant, and sta- bilizer. at room temperature the anhydrous form has a solubility of approximately 1 g in 30 ml of water, which improves in boiling water to approximately 1 g in 5 ml of water. it also exists as calcium gluconate (monohydrate). it is used as a source of calcium ions for sodium alginate gels, and as a calcium fortifier in baked goods, pud- dings, and dairy product analogs. it functions as a coagulation aid in milk and instant pudding powders and as a means of masking the bitter aftertaste of some artificial sweeteners.

Definition

ChEBI: Calcium gluconate is the calcium salt of D-gluconic acid. It has a role as a nutraceutical. It contains a D-gluconate.

brand name

Calglucon (Novartis).

Flammability and Explosibility

Non flammable

Industrial uses

calcium gluconate [Ca(C₆H₁₁O₇)₂] is used as a food additive in vitamin pills.injection of a 10% calcium gluconate has been recommended. It has to be kept in mind that the plasma Ca²⁺ level and any changes to the electrocardiogram (ECG) have to be carefully monitored.

Clinical Use

Hypocalcaemia

Safety Profile

Moderately toxic by subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects in infants by intramuscular route: dermatitis and fever. When heated to decomposition it emits acrid smoke and fumes. See also CALCIUM COMPOUNDS.

Veterinary Drugs and Treatments

Calcium salts are used for the prevention or treatment of hypocalcemic conditions.

Drug interactions

Potentially hazardous interactions with other drugs
Can impair absorption of some drugs, e.g. iron, ciprofloxacin.

Metabolism

Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails.

Purification Methods

Dissolve it in H2O, filter and precipitate it by adding MeOH. Filter off the solid and dry it in a vacuum at 85o. Alternatively, dissolve it in H2O, filter (from insoluble inorganic Ca) and evaporate it to dryness under vacuum at 85o. [March et al. J Am Pharm Assoc 41 366 1952, Beilstein 3 IV 1255.]

Preparation Products And Raw materials

Calcium gluconate Supplier

Global(678)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zibo Wei Bin Import & Export Trade Co. Ltd.	+86-0533-2091136 +8613864437655	ziboweibinmaoyi@163.com	China	100	58
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Mainchem Co., Ltd.	--	sarah@mainchem.com	China	6572	58

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