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Adriamycin Structure

Adriamycin

Chemical Properties

Melting point 205°C
Boiling point 617.77°C (rough estimate)
Density  1.3783 (rough estimate)
refractive index  1.6400 (estimate)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  ≥27.2 mg/mL in DMSO; insoluble in EtOH; ≥24.8 mg/mL in H2O with ultrasonic
form  solid
pka pKa 8.2 (Uncertain)
Water Solubility  Soluble
CAS DataBase Reference 23214-92-8
EWG's Food Scores 5
NCI Dictionary of Cancer Terms Adriamycin PFS; Adriamycin RDF; Doxil
FDA UNII 80168379AG
NCI Drug Dictionary Doxil
ATC code L01DB01
IARC 2A (Vol. 10, Sup 7) 1987
EPA Substance Registry System Doxorubicin (23214-92-8)

Safety

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H315-H319-H335-H350-H362
Precautionary statements P260-P263-P280
HS Code  2941900000
Hazardous Substances Data 23214-92-8(Hazardous Substances Data)
Toxicity An anthracycline cytotoxic antineoplastic that is produced by Streptomyces peucetius. The LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits DNA and RNA synthesis by intercalating in double-stranded DNA with the amino sugar in the minor groove and the 90-OH group of the anthracycline ring hydrogen-bonded to the adjacent guanine. It also alters membrane fluidity and ion transport, and generates free radicals through a cytochrome P450-mediated reductive process. In humans, it causes alopecia, stomatitis, nausea, vomiting, diarrhea, cardiotoxicity (manifested by tachycardia), and potentially fatal congestive heart failure.

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