Uses
Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.
Uses
Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.
Definition
ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.
brand name
Locoid (Ferndale); Locoid (Yamanouchi).
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
Contact allergens
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti-
sone. It represents the D2 group of corticosteroids, non
C 16 methylated with a C 17 ester: hydrocortisone
17-butyrate, hydrocortisone 17-valerate, hydrocortisone
aceponate (17-propionate and 21-acetate), methylpred-
nisolone aceponate, and prednicarbate. It is sometimes
hydrolyzed in vivo into hydrocortisone, giving allergic
reactions to group-A-sensitized people.
