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Zidovudine Structure

Zidovudine

Chemical Properties

Melting point 113-115 °C (lit.)
alpha  D25 +99° (c = 0.5 in water)
Boiling point 410.43°C (rough estimate)
Density  1.3382 (rough estimate)
refractive index  47 ° (C=1, H2O)
Flash point 9℃
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
pka pKa 9.53(H2O t = 25.0±0.1 I = 0.00) (Uncertain)
form  Powder
color  White to Off-white
Water Solubility  1-5 g/100 mL at 17 ºC
Sensitive  Light Sensitive & Hygroscopic
Merck  14,10123
BRN  3595791
BCS Class 1,3
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey HBOMLICNUCNMMY-BWZBUEFSSA-N
CAS DataBase Reference 30516-87-1(CAS DataBase Reference)
NCI Dictionary of Cancer Terms AZT; zidovudine
FDA UNII 4B9XT59T7S
NCI Drug Dictionary Retrovir
ATC code J05AF01
Proposition 65 List Zidovudine (AZT)
IARC 2B (Vol. 76) 2000
EPA Substance Registry System Thymidine, 3'-azido-3'-deoxy- (30516-87-1)

Safety

Symbol(GHS)
Signal wordDanger
Hazard statements H303-H225-H301+H311+H331-H370-H351
Precautionary statements P210-P260-P280-P301+P310-P311-P281-P501a-P201-P202-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  36/37/39-45-36-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  XP2072000
10
Hazard Note  Harmful
HS Code  29349990
Hazardous Substances Data 30516-87-1(Hazardous Substances Data)
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 3568, 3062, 3084, 3683 orally; >750 i.v. (all species) (Ayers)

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