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Aminophenazone

Product Name:
Aminophenazone
CAS No.
58-15-1
Chemical Name:
Aminophenazone
CBNumber:
CB1476086
Molecular Formula:
C13H17N3O
Formula Weight:
231.3
MOL File:
58-15-1.mol
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Aminophenazone Property

Melting point:
107-109 °C(lit.)
Boiling point:
373.38°C (rough estimate)
Density 
1.0744 (rough estimate)
refractive index 
1.6140 (estimate)
storage temp. 
Refrigerator
pka
pKa 5.0 (Uncertain)
form 
Crystalline Powder, Crystals and/or Chunks
color 
Off-white to brownish
Water Solubility 
5.55 g/100 mL
Sensitive 
Air & Light Sensitive
Merck 
14,474
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
InChIKey
RMMXTBMQSGEXHJ-UHFFFAOYSA-N
CAS DataBase Reference
58-15-1(CAS DataBase Reference)
NIST Chemistry Reference
Aminopyrine(58-15-1)
EPA Substance Registry System
Aminopyrine (58-15-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-21/22
Safety Statements 
26-36-36/37/39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
CD2625000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29331190
Hazardous Substances Data
58-15-1(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 1.7 g/kg (Hart)
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N-Bromosuccinimide Price More Price(9)

Sigma-Aldrich Gold
Product number:
D8015
Product name :
4-Dimethylaminoantipyrine
Purity:
reactive nitrogen species scavenger
Packaging:
25g
Price:
$64
Updated:
2019/12/02
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Buy
Sigma-Aldrich Gold
Product number:
D8015
Product name :
4-Dimethylaminoantipyrine
Purity:
reactive nitrogen species scavenger
Packaging:
100g
Price:
$177
Updated:
2019/12/02
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Buy
Alfa Aesar Gold
Product number:
B21436
Product name :
4-(Dimethylamino)antipyrine, 98+%
Packaging:
250g
Price:
$165
Updated:
2020/06/24
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Buy
Alfa Aesar Gold
Product number:
B21436
Product name :
4-(Dimethylamino)antipyrine, 98+%
Packaging:
50g
Price:
$45.3
Updated:
2020/06/24
Buy:
Buy
Cayman Chemical Gold
Product number:
15770
Product name :
Aminophenazone
Purity:
≥98%
Packaging:
25g
Price:
$59
Updated:
2020/06/24
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Buy
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Aminophenazone Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Antipyretic; analgesic.

Uses

Antipyretic;ACTH secretor

Definition

ChEBI: A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic proper ies.

brand name

Adexogan;Agevis;Algimicin anttitermico;Amidazopen;Amidozen;Anoixal;Antigripina;Areumal;Axiston;Balbion;Barsedan;Baukal suppositories;Bayer 1387 p;Bronchisan;Brufaneuseol;Butapyrine;Capsyka dr knapf;Capysal;Chinopyrin;Cibalgin;Ciclazon;Clinit;Coffan;Compral;Cusayth;Demolpas;Dentigoa;Depiral c;Dexa escopyrin;Dha 51;Dialpyrin;Digisab;Dimametten;Dimopyrin;Diprin;Dolo-attirin;Dolo-optineural;Dolorphen;Dolovosano;Donobin;Duerin;Dysmensan;Escopyrinus;Espasnatex;Eufibran;Euprogan;Febren;Febrosolvin;Fenodone;Fever;Flivalgin;Flumil;Framidone;Ftalazon;Funapon;Galenopyrin;Glucopirina;Glucopitina;Helvagit-f;Hemicraneal;Hisense-p;Influnal depot;Inst;Irgapyrine;Isoftal;Kalmine;Katareuma;Lagaflex;Latepyrine;Lauroanginol;Manslu;Medispanmin;Meloka;Neuro-demoplast;Nifedon;Nikartrone;Nostress;Optineural(analgesic);Optipax;Osadrine;Osmotipax;P.s.b.p.;Piracodid;Piradenil;Piradol;Pirasco;Piraseptolo.

World Health Organization (WHO)

Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)

General Description

Small colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Aminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.

Fire Hazard

Flash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.

Safety Profile

Human poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

It crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]

Aminophenazone Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Aminophenazone Suppliers

Global(217)Suppliers
J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
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86-21-61259102
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sh@meryer.com
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40268
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
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15880
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Alfa Aesar
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400-610-6006; 021-67582000
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021-67582001/03/05
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Energy Chemical
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Adamas Reagent, Ltd.
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XiaoGan ShenYuan ChemPharm co,ltd
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58-15-1, AminophenazoneRelated Search:

Dimethyl ether Dimethyl fumarate Dimethyl sulfoxide Glucosamine 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 4-Dimethylaminobenzaldehyde Acetaminophen N,N-Dimethyl-1,4-phenylenediamine 4-Dimethylaminopyridine Dimethyl sulfate 3-Dimethylaminopropylamine 1,4-DIMETHYLPYRAZOLE Dimethyl carbonate ETHANE Dimethyl sulfide Aminophenazone Chlorodimethylphenylsilane 2-Dimethylaminoethanol
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  • 4-DIMETHYLAMINOANTIPYRINE FREE BASE