ChemicalBook CAS DataBase List ACLARUBICIN HYDROCHLORIDE

ACLARUBICIN HYDROCHLORIDE

Product NameACLARUBICIN HYDROCHLORIDE
CAS75443-99-1
CBNumberCB2189954
MFC42H54ClNO15
MW848.33
EINECS278-209-3
MDL NumberMFCD00133024
MOL File75443-99-1.mol
MSDS FileSDS

Chemical Properties

Melting point	151-153℃
Boiling point	898℃
Flash point	>110°(230°F)
storage temp.	2-8°C
solubility	Soluble in DMSO or DMF at 25mg/ml
FDA UNII	501948RI66

Safety

Symbol(GHS)
Hazard statements	H301-H311-H331
Precautionary statements	P261-P280h-P301+P310a-P304+P340-P405-P501a
Hazard Codes	T
Risk Statements	23/24/25
Safety Statements	36/37/39-45
RIDADR	3249
RTECS	QI9283500
HazardClass	6.1(a)
PackingGroup	II

ACLARUBICIN HYDROCHLORIDE Price

Product number	Packaging	Price	Product description	Buy
Alfa Aesar J66842	5mg	$124	Aclarubicin hydrochloride, 90%	Buy
ChemScene CS-0079483	5mg	$280	AclacinomycinAhydrochloride 98.08%	Buy
ChemScene CS-0079483	10mg	$480	AclacinomycinAhydrochloride 98.08%	Buy
ChemScene CS-0079483	25mg	$980	AclacinomycinAhydrochloride 98.08%	Buy
AK Scientific 0647CB	10mg	$1197	Aclarubicinhydrochloride	Buy

ACLARUBICIN HYDROCHLORIDE Chemical Properties,Usage,Production

Definition

ChEBI: Aclarubicin hydrochloride is an anthracycline.

Biological Activity

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) is a fluorescent molecule and the first non-peptidic inhibitor discovered to have discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. It is also a dual inhibitor of topoisomerase I and II (topoisomerase I and II). It is an effective anthracycline chemotherapeutic agent for blood cancer and solid tumor related research.

in vitro

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

in vivo

Aclarubicin hydrochloride(Aclacinomycin A) is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD ₅₀ (76.5 mg/kg) is about twice the iv LD ₅₀ (35.6 mg/kg) in mice ^[4 .
Aclacinomycin A ( 0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model ^[4 .

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Animal Model:	DBA/2, CDF ₁ ( BALB/c×DBA/2) mice with Leukemia P-388 ^[4 .
Dosage:	0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration:	Intraperit oneal administration daily for 10 days starting 3 hr after transplantation.
Result:	Inhibited tumor growth.

target

20S proteasome.
Topoisomerase I and II.

Preparation Products And Raw materials

ACLARUBICIN HYDROCHLORIDE Suppliers

Global(40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SIGMA-RBI	--		Switzerland	6913	91

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