ChemicalBook CAS DataBase List N,N,N',N'-Tetramethylethylenediamine

N,N,N',N'-Tetramethylethylenediamine

Product NameN,N,N',N'-Tetramethylethylenediamine
CAS110-18-9
CBNumberCB2446761
MFC6H16N2
MW116.2
EINECS203-744-6
MDL NumberMFCD00008335
MOL File110-18-9.mol

Chemical Properties

Melting point	−55 °C(lit.)
Boiling point	120-122 °C(lit.)
Density	0.775 g/mL at 20 °C(lit.)
vapor density	4 (vs air)
vapor pressure	21 hPa (20 °C)
refractive index	n20/D 1.4179(lit.)
Flash point	50 °F
storage temp.	Store below +30°C.
solubility	H₂O: 10 mg/mL at 20 °C, clear, colorless
form	Liquid
pka	10.40, 8.26(at 25℃)
Specific Gravity	0.777 (20/4℃)
color	Clear colorless to slightly yellow
PH	8.0-8.5 (0.1g/l, H2O, 20℃)
Odor	Amine like
explosive limit	1-9%(V)
Water Solubility	miscible
Sensitive	Hygroscopic
Merck	14,9134
BRN	1732991
Stability	Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.
InChIKey	DMQSHEKGGUOYJS-UHFFFAOYSA-N
LogP	-0.13 at 20.2℃
Indirect Additives used in Food Contact Substances	N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE
CAS DataBase Reference	110-18-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	K90JUB7941
NIST Chemistry Reference	1,2-Ethanediamine, N,N,N',N'-tetramethyl-(110-18-9)
EPA Substance Registry System	Tetramethylethylenediamine (110-18-9)

Safety

Symbol(GHS)

Signal word

Danger

Hazard statements

H225-H301+H331-H314

Precautionary statements

P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

F,C,Xi

Risk Statements

11-20/22-34-20/21/22

Safety Statements

16-26-36/37/39-45

RIDADR

UN 2372 3/PG 2

WGK Germany

RTECS

KV7175000

3-8-10-34

Autoignition Temperature

145 °C

Hazard Note

Irritant

TSCA

Yes

HazardClass

PackingGroup

HS Code

29212900

Hazardous Substances Data

110-18-9(Hazardous Substances Data)

NFPA 704:

	3
3		0

N,N,N',N'-Tetramethylethylenediamine Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich 8.08742	5ml	$32.3	N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	Buy
Sigma-Aldrich 8.08742	250ML	$55.9	N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	Buy
Sigma-Aldrich 8.08742	1L	$179	N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	Buy
Sigma-Aldrich 411019	2l	$347.6	N,N,N′,N′-Tetramethyl ethylenediamine ≥99.5%, purified by redistillation	Buy
Sigma-Aldrich 411019	1l	$453	N,N,N′,N′-Tetramethyl ethylenediamine ≥99.5%, purified by redistillation	Buy

N,N,N',N'-Tetramethylethylenediamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to slightly yellow liquid

Uses

N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent. It is also used for the separation of proteins or nucleic acids. Further, it is employed as a ligand for metal ions like zinc and copper. It is actively involved in the formation of anionic organometallic complex.

Definition

ChEBI: N,N,N',N'-tetramethylethylenediamine is an ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. It has a role as a chelator and a catalyst.

General Description

1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Sensitive to heat and may be sensitive to air .

Reactivity Profile

N,N,N',N'-Tetramethylethylenediamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by slun contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Purification Methods

Dry TMEDA partially with molecular sieves (Linde type 4A), then distil it in a vacuum from butyl lithium. This treatment removes all traces of primary and secondary amines and water. [Hay et al. J Chem Soc, Faraday Trans 1 68 1 1972.] Or dry it with KOH pellets, reflux for 2hours with one-sixth its weight of n-butyric anhydride (to remove primary and secondary amines) and fractionally distil it. Reflux it with fresh KOH, and distil it under nitrogen. [Cram & Wilson J Am Chem Soc 85 1245 1963.] It was also distilled from Na. Store it sealed under N2. The dipicrate has m 263o(dec). [Beilstein 4 H 250, 4 I 415, 4 II 690, 4 III 512, 4 IV 1172.]

N,N,N',N'-Tetramethylethylenediamine synthesis

Preparation Products And Raw materials

N,N,N',N'-Tetramethylethylenediamine Supplier

Global(579)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
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