T-3775440 hydrochloride
- Product NameT-3775440 hydrochloride
- CAS1422535-52-1
- CBNumberCB24668572
- MFC18H23ClN4O
- MW346.86
- EINECS604-604-1
- MDL NumberMFCD31692337
- MOL File1422535-52-1.mol
Chemical Properties
storage temp. | Store at -20°C |
solubility | DMSO : ≥ 30.18 mg/mL (87.01 mM) |
T-3775440 hydrochloride Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Biosynth Carbosynth BT168491 | 5mg | $300 | T 3775440 hydrochloride |
Buy |
ChemScene CS-0023825 | 5mg | $450 | T-3775440hydrochloride 99.13% |
Buy |
AK Scientific 7208EA | 5mg | $455 | T-3775440Hydrochloride |
Buy |
ChemScene CS-0023825 | 10mg | $750 | T-3775440hydrochloride 99.13% |
Buy |
Biosynth Carbosynth BT168491 | 25mg | $905 | T 3775440 hydrochloride |
Buy |
T-3775440 hydrochloride Chemical Properties,Usage,Production
Biological Activity
Target | Value |
LSD1 () | 2.1 nM |
Biological Activity
T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM.in vitro
T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases.
in vivo
T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model.
Preparation Products And Raw materials
T-3775440 hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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+undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 | |
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marketing@targetmol.com | United States | 19892 | 58 | |
+86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 | |
86-571-88216897,88216896 13588875226 |
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+1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 | |
15962211760 | 2665833871@qq.com | China | 548 | 58 | |
028-81700200 18116577057 |
3003855609@qq.com | China | 7892 | 56 | |
16314854226 | info@bocsci.com | United States | 9926 | 65 |
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