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Flutamide

Product Name:
Flutamide
CAS No.
13311-84-7
Chemical Name:
Flutamide
CBNumber:
CB2468110
Molecular Formula:
C11H11F3N2O3
Formula Weight:
276.21
MOL File:
13311-84-7.mol
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Flutamide Property

Melting point:
112 °C
Boiling point:
400.3±45.0 °C(Predicted)
Density 
1.3649 (estimate)
storage temp. 
Store at RT
solubility 
Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
form 
neat
pka
13.12±0.70(Predicted)
Merck 
14,4208
CAS DataBase Reference
13311-84-7(CAS DataBase Reference)
EPA Substance Registry System
Flutamide (13311-84-7)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-63-36/37/38
Safety Statements 
22-36-36/37/39-27-26
WGK Germany 
3
RTECS 
UG5700000
HS Code 
29242990
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N-Bromosuccinimide Price More Price(12)

Sigma-Aldrich Gold
Product number:
94495
Product name :
Flutamide
Purity:
certified reference material, TraceCERT
Packaging:
50mg
Price:
$190
Updated:
2020/08/18
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Buy
Sigma-Aldrich Gold
Product number:
1285851
Product name :
Flutamide
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
200mg
Price:
$366
Updated:
2020/08/18
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Buy
TCI Chemical Gold
Product number:
F0663
Product name :
Flutamide
Purity:
>98.0%(GC)
Packaging:
5g
Price:
$45
Updated:
2020/06/24
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Buy
TCI Chemical Gold
Product number:
F0663
Product name :
Flutamide
Purity:
>98.0%(GC)
Packaging:
25g
Price:
$133
Updated:
2020/06/24
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Buy
Cayman Chemical Gold
Product number:
20359
Product name :
Flutamide
Purity:
≥98%
Packaging:
5g
Price:
$69
Updated:
2020/06/24
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Flutamide Chemical Properties,Usage,Production

Description

Flutamide is a kind of synthetic, non-steroidal antiandrogen which is mainly used for the treatment of prostate cancer. It is a kind of toluidine derivative and a nonsteroidal antiandrogen with a similar structure of bicalutamide and nilutamide. The mechanism of its anti-cancer property is through acting as a selective antagonist of the androgen receptor (AR), preventing androgens such as testosterone and its active metabolite dihydrotestosterone from binding to ARs in the prostate gland. This process inhibits androgen-dependent DNA and protein synthesis in the tumor cell. Therefore, it can prevent androgens from stimulating the growth of prostate cancer cells. Moreover, it can also be used for the treatment of hyperandrogenism in women. It is quite effective in alleviating symptoms such as acne, seborrhea, hirsutism and androgenetic alopecia. Finally, it is also useful as a component in the transgender hormone therapy.

References

https://en.wikipedia.org/wiki/Flutamide
https://pubchem.ncbi.nlm.nih.gov/compound/flutamide#section=Top

Description

Flutamide is an orally active, non-steroidal antiandrogen indicated for the treatment of prostatic cancer in both castrates and noncastrates.

Chemical Properties

Light Yellow Solid

Originator

scheting (USA)

History

Flutamide was first described as a member of a series of N-acyl anilides synthesized at Monsanto in the 1960s during a compound finding program aiming at bacteriostatic agents. Soon after, at Schering Corp., the compound was characterized pharmacologically and further developed as SCH-13521. It was found that flutamide inhibits agonist action at the AR by replacing the agonist at the ligand binding site, being the first nonsteroidal compound possessing anti-androgenic activity in animals. In contrast to steroidal anti-androgens, for instance, cyproterone acetate, which also displays significant progestational activity, flutamide has no other hormonal activity. There is also no reduction of serum testosterone levels seen with flutamide but rather a slight increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) resulting in elevated serum testosterone levels. This accounts for the beneficial maintenance of libido and potency in sexually active patients. On the other hand, elevated serum estradiol levels resulting from peripheral testosterone aromatization leading to gynecomastia were observed in patients.

Uses

Antiandrogen; antineoplastic (hormonal).

Uses

neuroleptic

Uses

Flutamide is a nonsteroidal antiandrogen drug; antineoplastic (hormonal).

Uses

Besides prostate cancer, flutamide has also been tested and/or used off-label in other hyperandrogenism-related disorders like benign prostatic hyperplasia, acne vulgaris, and hirsutism syndrome. Due to its teratogenic potential, flutamide is restricted for premenopausal women and used only in combination with effective contraception.

Indications

Flutamide (Eulexin) is a nonsteroidal androgen receptor antagonist that inhibits androgen binding to its nuclear receptor. It is effective in inducing prostatic regression and is approved for the treatment of prostatic carcinoma. For maximum clinical effectiveness it has to be used in combination with a GnRH antagonist (e.g., leuprolide acetate) that inhibits androgen production. Flutamide may eventually be used for the treatment of hirsutism and male pattern baldness in women if a topical preparation is developed.

Indications

Flutamide (Eulexin) is a nonsteroidal antiandrogen compound that competes with testosterone for binding to androgen receptors. The drug is well absorbed on oral administration. It is an active agent in the hormonal therapy of cancer of the prostate and has been shown to complement the pharmacological castration produced by the gonadotropin-releasing hormone (GnRH) agonist leuprolide. Flutamide prevents the stimulation of tumor growth that may occur as a result of the transient increase in testosterone secretion after the initiation of leuprolide therapy. The most common side effects of flutamide are those expected with androgen blockade: hot flashes, loss of libido, and impotence. Mild nausea and diarrhea occur in about 10% of patients.

Indications

Flutamide is a prodrug possessing only weak androgen antagonistic activity of its own. It is oxidized in vivo to the active principle hydroxyflutamide (6) as primary metabolite.The elimination half-life of hydroxyflutamide is relatively short, 4–6.6 h in patients after a single oral 250 mg dose of flutamide. Therefore, oral dosing of 250 mg flutamide three times daily was applied clinically. The first introduction into clinical studies was achieved in 1975 as single agent in the first-line treatment of advanced prostate carcinoma. In the United States, flutamide was finally approved by FDA in 1989 for the treatment of metastatic prostate cancer in combination with a luteinizing hormone-releasing hormone (LHRH, also referred to as gonadotropin-releasing hormone (GnRH)) agonist, for instance, leuprorelin acetate (Leuprolide(R), Lupron(R)) or goserelin acetate (Zoladex(R)).The combined androgen blockade by flutamide plus an LHRH agonist or surgical castration was introduced in order to maximize the effects of androgen ablation. Flutamide also inhibits the secretion of androgens from the adrenal gland, which is not impaired by chemical castration with LHRH agonists or by surgical castration. In addition, the AR antagonist avoids the unacceptable initial tumor flare that occurs when LHRH agonists are given alone.
Favorable response to flutamide was seen with advanced prostate carcinoma patients after single-agent treatment as well as after combination treatment. The progression of the disease was slowed and the lifetime of patients was extended. For instance, the National Cancer Institute (NCI) initiated a trial (INT-0036) and concluded that the combination of leuprolide with flutamide was more effective than leuprolide alone in patients with advanced prostate cancer. However, significant side effects were also reported.The most frequently observed adverse events are summarized in Table 1. Flutamide evidently amplifies some of the LHRH agonist-induced side effects.

Table 1 Side effects of LHRH antagonist alone and in combination with flutamide.

Manufacturing Process

To a stirred, cooled solution of 100 g of 4-nitro-3-trifluoromethylaniline in 400 ml of pyridine, slowly and in a dropwise fashion, add 54 g of isobutyrylchloride and then heat the reaction mixture on a steam bath for 1.5 hours. Cool and pour the resulting mixture into ice water, filter and waterwash the crude anilide and crystallize the product of this example from benzene to obtain analytically pure material, MP 111.5°C to 112.5°C.

brand name

Eulexin (Schering);DROGENIL.

Therapeutic Function

Antiandrogen

General Description

Flutamide, 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, is dosed 3 times daily(250-mg dose; 750-mg total daily dose). A major metaboliteof flutamide, hydroxyflutamide, is a more potent AR antagonistthan the parent compound. This metabolite, which ispresent at a much higher steady-state concentration than isflutamide, contributes a significant amount of the antiandrogen action of this drug. A limiting factor in the useof flutamide is hepatotoxicity in from 1% to 5% of patients.Although the hepatotoxicity usually is reversible followingcessation of treatment, rare cases of death associated withhepatic failure have been reported to be associated with flutamidetherapy. Diarrhea is also a limiting side effect withflutamide therapy for some patients.

Contact allergens

Flutamide is an antiandrogenic hormonal antineoplas tic drug that can induce photosensitivity and porphy ria-like eruption.

Clinical Use

Flutamide is a pure antagonist, whereas 2-hydroxyflutamide is a more potent AR antagonist but also can activate the androgenic receptor at higher concentrations. These findings raise the possibility that increased conversion of flutamide to 2-hydroxyflutamide or accumulation of 2-hydroxyflutamide in cells may contribute to the anomalous responses to flutamide that are observed in some advanced prostate cancers.

Flutamide Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Flutamide Suppliers

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Shanghai Boyle Chemical Co., Ltd.
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13311-84-7, FlutamideRelated Search:

Bicalutamide 2-HYDROXY-FLUTAMIDE,Hydroxy-Flutamide(Flutamide metabolite) N-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)(PHENYLCYCLOPENTYL)FORMAMIDE 2-METHYL-D3-N-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-2-TRIMETHYLSILYLOXY-PROPAMIDE-3,3,3-D3 Hydroxy FlutaMide-d6 Flutamide N,N'-Methylenebisacrylamide N,N-Dimethylacetamide N,N-Dimethylformamide Tribenuron methyl Methyl PHENYL VALERATE Methyl salicylate Parathion-methyl Thiophanate-methyl Methyl acetate Kresoxim-methyl Methyl bromide
  • TIMTEC-BB SBB006930
  • N1-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]-2-METHYLPROPANAMIDE
  • 2-METHYL-N-(4'-NITRO-3'-(TRIFLUOROMETHYL)PHENYL)PROPANAMIDE
  • 2-METHYL-N-(4-NITRO-3-[TRIFLUOROMETHYL]PHENYL)PROPANAMIDE
  • FLUTAMIDE
  • AURORA KA-860
  • 2-Methyl-N-[4-nitro-3-(trifluoromethyl)-phenyl]-propionamide
  • Flutamide USP25
  • FlutamideUsp27
  • FLUTAMIDE (2-METHYL-N-(4''-NITRO-3''-(TRIFLUOROMETHYL)PHENYL)PROPANAMIDE)
  • Drognil
  • Euflex
  • Eulexin
  • N-(Isopropylcarbonyl)-4-nitro-3-trifluoromethylaniline
  • 2-Methyl-N-[4-nitro-3-(trifluoronethyl)phenyl]propanamide
  • Drogenil
  • Eu.1exim
  • Eunex
  • Fiutamide
  • Flucinom
  • Fugerel
  • Niftolid
  • N-[4-Nitro-3-(trifluoromethyl)phenyl]isoButyramide
  • trihalonitramide
  • N-[3-(Trifluoromethyl)-4-nitrophenyl]-2-methylpropanamide
  • Flutamide (2-Methyl-N-(4'-nitro-3'-(trifluoromethyl)phenyl)propa
  • Flutamide (200 mg)
  • SCH 13521;FLUTAMIDE
  • NSC 147834
  • NSC 215876
  • Odyne
  • 4'-Nitro-3'-(trifluoromethyl)isobutyranilide 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide
  • FlutaMide(Sch 13521)
  • Flutamide for system suitability
  • Flutamide, 98%, an androgen receptor antagonist
  • Flutamide Usp30
  • 2-methyl-4’-nitro-alpha,alpha,alpha-triflouro-m-propionotoluidid
  • 2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-propanamid
  • 4’-nitro-3’-trifluoromethylisobutyranilide
  • alpha,alpha,alpha-trifluoro-2-methyl-4’-nitro-m-propionotoluidide
  • niftholide
  • niftolide
  • sch13521
  • Flutamide RS
  • Flutamide for system suitability CRS
  • Flutamide&gt
  • Flutamide CRS
  • 13311-84-7
  • C11H11F3N2O3
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Steroid Hormones
  • Hormones
  • Other Steroid Products
  • Cytokines, Growth Factors and Hormones
  • Pharmaceutical raw material
  • INAPSINE
Description References