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REMIFENTANIL

Product Name:
REMIFENTANIL
CAS No.
132875-61-7
Chemical Name:
REMIFENTANIL
CBNumber:
CB2470854
Molecular Formula:
C20H28N2O5
Formula Weight:
376.45
MOL File:
132875-61-7.mol
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REMIFENTANIL Property

Boiling point:
487.8±45.0 °C(Predicted)
Density 
1.171±0.06 g/cm3(Predicted)
pka
6.65±0.20(Predicted)
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REMIFENTANIL Chemical Properties,Usage,Production

Uses

Analgesic.

Definition

ChEBI: A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoy aniline.

brand name

Ultiva (Abbott).

World Health Organization (WHO)

Remifentanil is defined as an opioid narcotic with an addictionforming and addiction-sustaining liability similar to morphine.

General Description

Remifentanil (Ultiva) was designed as a “soft drug.” Softdrugs are designed to undergo metabolism quickly and thushave ultrashort durations of action. In place of the ethylaromatic ring seen on the other piperidine opioids, remifentanilhas an ester group. This ester group is metabolizedby esterases in the blood and tissue to a weaklyactive metabolite (1:300–1:1,000 the potency of remifentanil). The n-octanol/water partition coefficient ofremifentanil is 17.9. The pKa of remifentanil is 7.07, thus itis predominately unionized at physiological pH. Both ofthese properties account for its rapid distribution across theblood-brain barrier (<1 minute). The ester hydrolysis leadsto a quick recovery (5–10 minutes) independent of durationof drug administration, renal, or liver function. The favorablepharmacodynamics of remifentanil have led to its usefor induction and maintenance of surgical anesthesia.

REMIFENTANIL Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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132875-61-7, REMIFENTANILRelated Search:

FENTANYL 1-PIPERIDINEPROPIONIC ACID Remifentanil-13C6 Hydrochloride REMIFENTANIL ADVANCED INTERMEDIATE Remifentanil Hydrochloride
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