ChemicalBook > CAS DataBase List > ethaverine

ethaverine

Product Name:
ethaverine
CAS No.
486-47-5
Chemical Name:
ethaverine
CBNumber:
CB2929569
Molecular Formula:
C24H29NO4
Formula Weight:
395.49
MOL File:
486-47-5.mol
More
Less

ethaverine Property

Melting point:
99-101°
Boiling point:
519.44°C (rough estimate)
Density 
1.1668 (rough estimate)
refractive index 
1.6000 (estimate)
pka
6.41±0.40(Predicted)
More
Less

ethaverine Chemical Properties,Usage,Production

Chemical Properties

Crystals.Insoluble in water; very soluble in hot alcohol; slightly soluble in ether and chloroform.

Originator

Ethaverine,Shanghai Lansheng

Uses

Ethaverine is an analogue of Papaverine (P190500), an antispasmodic. An isoquinoline derivative with the potential for antimicrobial, antimalarial and cytotoxic antiviral agents.

Manufacturing Process

(1) 1 part of 2-(3,4-diethoxy-phenyl)-N-[2-(3,4-diethoxy-phenyl)-2-hydroxyethyl]acetamide (homoveratroyl hydroxyhomo-veratrylamine), prepared from 2-amino-1-(3,4-diethoxy-phenyl)ethanol and (3,4-diethoxy-phenyl)acetyl chloride, is dissolved in a neutral solvent, such as, for example, chloroform or benzene. Thereupon, 1 to 3 parts of phosphorus oxychloride are added to the resulting solution and the no whole is heated for some hours under a reflux condenser. It should be pointed out here that it is also possible to occur by allowing the amide solution to flow on to the phosphorus oxychloride with the application of heat or in the cold. Instead of this, it is also possible to carry out the reaction in such a way that the reaction mixture is first allowed to stand in the cold. Then it completed by heating. The base produced in both cases is obtained by shaking with chloroform after distilling off the solvent and after alkalization. MP: 145°-147°C.
(2) 1 part of 2-(3,4-dimethoxyphenyl)ethylamine is dissolved in 2 parts of benzene, 1 to 2 parts of phosphorus pentachloride are added thereto and the whole is heated to boiling. After heating for several hours, the base, which is formed can be isolated as above described. MP: 147°C.
(3) 1 part of N-(3,4-diethoxyphenylacetyl)-β-oxy-β-(3,4- diethoxyphenyl)ethylamine is dissolved in benzene or chloroform, mixed with 1 to 3 parts by weight of phosphorus oxychloride and boiled under a reflux condenser for 3 hours whereupon 6,7-diethoxy-1-(3',4'- diethoxybenzyl)isoquinoline base can be isolated in the usual way. MP: 99°- 101°C.

Therapeutic Function

Spasmolytic, Vasodilator, Antiarrhythmic

Less

ethaverine Suppliers

Global(10)Suppliers
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel:
021-33632979
Fax:
021-34692979
Email:
info@tsbiochem.com
Country:
China
ProdList:
8074
Advantage:
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel:
400-002-6226
Email:
sales@biochemall.cn
Country:
China
ProdList:
54467
Advantage:
58

486-47-5, ethaverineRelated Search:

6-Desmethyl Papaverine 6,7-DIMETHOXYISOQUINOLINE PAPAVERINE HYDROCHLORIDE papaveroline 6-Methoxyisoquinoline Isoquinolin-6-ol ethaverine ethaverine hydrochloride 1-Benzylisoquinoline
  • ethaverine
  • 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline
  • Isoquinoline, 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-
  • 486-47-5
  • 985-11-7
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals