ChemicalBook > CAS DataBase List > Acesulfame potassium

Acesulfame potassium

Product Name:
Acesulfame potassium
CAS No.
55589-62-3
Chemical Name:
Acesulfame potassium
CBNumber:
CB3224119
Molecular Formula:
C4H4KNO4S
Formula Weight:
201.24
MOL File:
55589-62-3.mol
More
Less

Acesulfame potassium Property

Melting point:
229-232°C (dec.)
Density 
(solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
storage temp. 
0-6°C
solubility 
Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
form 
neat
color 
White crystalline solid
Odor
odorless with sweet taste
Water Solubility 
almost transparency
Merck 
14,37
BRN 
3637857
CAS DataBase Reference
55589-62-3(CAS DataBase Reference)
EPA Substance Registry System
Acesulfame-potassium (55589-62-3)
More
Less

Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
1
RTECS 
RP4489165
HS Code 
2934990002
Toxicity
LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)
More
Less

N-Bromosuccinimide Price More Price(9)

Sigma-Aldrich Gold
Product number:
04054
Product name :
Acesulfame K
Purity:
for food analysis, ≥99.0%
Packaging:
25g
Price:
$69
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
04054
Product name :
Acesulfame K
Purity:
for food analysis, ≥99.0%
Packaging:
100g
Price:
$191
Updated:
2019/12/02
Buy:
Buy
TCI Chemical Gold
Product number:
A1490
Product name :
Acesulfame K
Purity:
>98.0%(T)
Packaging:
25g
Price:
$40
Updated:
2020/06/24
Buy:
Buy
TCI Chemical Gold
Product number:
A1490
Product name :
Acesulfame K
Purity:
>98.0%(T)
Packaging:
100g
Price:
$120
Updated:
2020/06/24
Buy:
Buy
Sigma-Aldrich Gold
Product number:
A0070000
Product name :
Acesulfame potassium
Purity:
European Pharmacopoeia (EP) Reference Standard
Packaging:
a0070000
Price:
$183
Updated:
2019/12/02
Buy:
Buy
More
Less

Acesulfame potassium Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Chemical Properties

Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.

History

Acesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.

Uses

'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.

Uses

Potassium salt as sweetener for foods, cosmetics.

Uses

Acesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide. This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener. The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature.
Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.

Production Methods

Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.

Production Methods

The principal commercial process for acesulfame-K is depicted below: 图

Pharmaceutical Applications

Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.

Safety Profile

When heated to decompositionemits toxic fumes of SOx.

Safety

Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, oral): 6.9–8.0 g/kg

storage

Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.

Regulatory Status

Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.

Acesulfame potassium Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

Less

Acesulfame potassium Suppliers

Global(290)Suppliers
Shanghai Boyle Chemical Co., Ltd.
Tel:
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax:
+86-21-57758967
Email:
sales@boylechem.com
Country:
China
ProdList:
2214
Advantage:
55
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Fax:
86-21-61259102
Email:
sh@meryer.com
Country:
China
ProdList:
40268
Advantage:
62
future industrial shanghai co., ltd
Tel:
400-0066-400;021-60496031
Fax:
021-55660885
Email:
sales@jonln.com;sales@jonln.com
Country:
China
ProdList:
2000
Advantage:
65
TAIYUAN RHF CO.,LTD.
Tel:
+86 351 7031519
Fax:
+86 351 7031519
Email:
sales@RHFChem.com
Country:
China
ProdList:
2347
Advantage:
56
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Fax:
021-67121385
Email:
Sales-CN@TCIchemicals.com
Country:
China
ProdList:
24555
Advantage:
81
Energy Chemical
Tel:
021-58432009
Fax:
021-58436166-800
Email:
sales8178@energy-chemical.com
Country:
China
ProdList:
44026
Advantage:
61
Pure Chemistry Scientific Inc.
Tel:
001-857-928-2050 or 1-888-588-9418
Fax:
001-617-206-9595
Email:
sales@chemreagents.com
Country:
United States
ProdList:
9918
Advantage:
62
Adamas Reagent, Ltd.
Tel:
400-600-9262
Email:
bxy@titansci.com
Country:
China
ProdList:
13918
Advantage:
59

55589-62-3, Acesulfame potassiumRelated Search:

Acesulfame Aspartame Acesulfame potassium Potassium Acetate Potassium chloride Potassium POTASSIUM CYANIDE Thiamethoxam Potassium Citrate Potassium chlorate Hydrochlorothiazide Potassium iodide Buprofezin Potassium nitrate Potassium persulfate Potassium sorbate Phenothiazine
  • acesulfame
  • ACESULFAME POTASSIUM
  • potassium 6-methyl-2,2-dioxo-4-oxathiazinolate
  • AcesuL
  • fame potassium [NF]
  • Acessulfame-K
  • 1,2,3-oxathiazin-4(3h)-one,6-methyl-,2,2-dioxide,potassiumsalt
  • 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one2,2-dioxidepotassiumsalt
  • potassiumacesulfame
  • Potassiumsaltof6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide
  • sunett
  • Acesulfamum Kalicum
  • ACESULFAME-K FCC 99-101%
  • ACESULFAME-K(P)
  • AcesulfaMe PotassiuM,NF
  • PotassiuM 6-Methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide
  • 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt (1:1)
  • SUNETTE
  • SWEET ONE
  • RARECHEM AM UC 0205
  • POTASSIUM 6-METHYL-1,2,3-OXATHIAZIN-4(3H)-ONE 2,2-DIOXIDE
  • Acesulfame potassium Joyce
  • 6-METHYL-1,2,3-OXATHIAZIN-4(3H)-ONE 2,2-DIOXIDE POTASSIUM SALT
  • ACESULFAME K
  • ACESULFAME POTASSIUM SALT
  • ACESULFAME POTASSIUM
  • ACESULFAME POTASSIUM(AK)
  • ACESULPHAME-K
  • POTASSIUMACESULFAMEK
  • ASPARTAMEACESULPHAMESALT
  • ACESULPHAMEPOTASSIUM
  • 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid, Kaliumsalz
  • Blended sweetener of acesulfame-kwith aspartame
  • Acesulfaml-K
  • 3,4-Dihydro-6-methyl-3-potassio-4-oxo-1,2,3-oxathiazine 2,2-dioxide
  • 3,4-Dihydro-6-methyl-4-oxo-3-potassio-1,2,3-oxathiazine 2,2-dioxide
  • Ccris 1032
  • Einecs 259-715-3
  • Acesulfame K,6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
  • Acesulfame Potassium (200 mg)
  • 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-Dioxide Potassium Salt Potassium 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-Dioxide
  • Ak Candy
  • 55589-62-3
  • C4H4NO4KS
  • C4H4NO4SKC4H4KNO4S
  • C4H4KNO4S
  • C4H5NO4SK
  • C4H5KNO4S
  • C4H4SNKO4
  • C4H4SKNO4
  • C4H4KNSO4
  • Typical Metal Compounds
  • Classes of Metal Compounds
  • K (Potassium) Compounds (excluding simple potassium salts)
  • Sweetener
  • Food & Beverage Standards
  • Chromatography
  • Analytical Standards