Chemical Properties
White to light yellow crystal powder
Uses
3,4-Dichlorobenzoic acid was employed as internal standard during the multiresidue analysis of pharmaceuticals and personal care products by ultra performance liquid chromatography-positive/negative electrospray tandem mass spectrometry. It was used to study the metabolic fate of 4-chloro-3,5-dinitrobenzoic acid.
Definition
ChEBI: A chlorobenzoic acid carrying chloro substituents at positions 3 and 4.
Synthesis Reference(s)
Journal of the American Chemical Society, 98, p. 843, 1976
DOI: 10.1021/ja00419a038
Safety Profile
Poison by
subcutaneous route. When heated to
decomposition it emits toxic fumes of Cl-.
Purification Methods
Crystallise the acid from aqueous EtOH (charcoal) or acetic acid. [Beilstein 9 IV 1006.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.]
