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Pseudoephedrine

Product Name:
Pseudoephedrine
CAS No.
90-82-4
Chemical Name:
Pseudoephedrine
CBNumber:
CB3699555
Molecular Formula:
C10H15NO
Formula Weight:
165.23
MOL File:
90-82-4.mol
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Pseudoephedrine Property

Melting point:
118-120 °C
alpha 
52 º (c=0.6, EtOH)
Boiling point:
293.09°C (rough estimate)
Density 
1.0203 (rough estimate)
refractive index 
1.5200 (estimate)
Flash point:
9℃
storage temp. 
?20°C
pka
pKa 9.73(H2O,t=25±0.5,I=0.01)(Approximate)
optical activity
[α]20/D +52°, c = 0.6 in ethanol
Water Solubility 
<0.5g/L(er)
Merck 
13,8007
BRN 
2414132
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents. May discolour upon exposure to light.
CAS DataBase Reference
90-82-4(CAS DataBase Reference)
NIST Chemistry Reference
Pseudoephedrine, (+)-(90-82-4)
EPA Substance Registry System
Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.S)- (90-82-4)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
20/21/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-37/39-45-36/37-16-7
RIDADR 
1544
WGK Germany 
3
RTECS 
UL5800000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
90-82-4(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 660mg/kg
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N-Bromosuccinimide Price More Price(6)

Sigma-Aldrich Gold
Product number:
P-035
Product name :
(S,S)-(+)-Pseudoephedrine solution
Packaging:
035-1ml
Price:
$19.6
Updated:
2019/12/02
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Buy
Sigma-Aldrich Gold
Product number:
287636
Product name :
(1S,2S)-(+)-Pseudoephedrine
Purity:
98%
Packaging:
100g
Price:
$268
Updated:
2019/12/02
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Buy
Cayman Chemical Gold
Product number:
14209
Product name :
(1S,2S)-(+)-Pseudoephedrine
Packaging:
1mg
Price:
$16
Updated:
2020/06/24
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Cayman Chemical Gold
Product number:
14209
Product name :
(1S,2S)-(+)-Pseudoephedrine
Packaging:
5mg
Price:
$45
Updated:
2020/06/24
Buy:
Buy
Sigma-Aldrich Gold
Product number:
287636
Product name :
(1S,2S)-(+)-Pseudoephedrine
Purity:
98%
Packaging:
5g
Price:
$48.5
Updated:
2019/12/02
Buy:
Buy
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Pseudoephedrine Chemical Properties,Usage,Production

Chemical Properties

white crystals

Uses

Decongestant.

Definition

ChEBI: A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group.

brand name

Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).

General Description

(Sudafed, Afrinol, Drixoral) isthe (S,S) diastereoisomer of ephedrine. Whereas ephedrinehas a mixed mechanism of action, L-(+)-pseudoephedrineacts mostly by an indirect mechanism and has virtually nodirect activity. The structural basis for this difference inmechanism is the stereochemistry of the carbon atom possessingthe β-OH group. In pseudoephedrine, this carbon atompossesses the (S) configuration, the wrong stereochemistryat this center for a direct-acting effect at adrenoceptors.Although it crosses the BBB (log P=1.05, pKa=9.38),L-(+)-pseudoephedrine’s lack of direct activity affords fewerCNS effects than does ephedrine. It is a naturally occurringalkaloid from the Ephedra species. This agent is found inmany OTC nasal decongestant and cold medications.Although it is less prone to increase blood pressure thanephedrine, it should be used with caution in hypertensiveindividuals, and it should not be used in combination withMAO inhibitors.

Contact allergens

This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.

Purification Methods

Crystallise the amine from dry diethyl ether, or from water and dry it in a vacuum desiccator. [Beilstein 13 IV 1878.]

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90-82-4, PseudoephedrineRelated Search:

(1R, 2R)-PSEUDOEPHEDRINE-(S)-2-METHYLHYDROCINNAMAMIDE P-CHLORO-NOR-PSEUDOEPHEDRINE HYDROCHLORIDE CATHINE HYDROCHLORIDE Pseudoephedrine, hydrochloride, (-)- (8CI) P-Hydroxynorpseudoephedrine 3-METHYLAMINO-1-PHENYL-1-PROPANOL (S)-3-METHYLAMINO-1-PHENYL-1-PROPANOL D-PSEUDOEPHEDRINE (D3) (1S,2R)-2-Methylamino-1-phenyl-1-propanol hydrochloride, D-α-(1-Methylaminoethyl)benzyl alcohol hydrochloride,(1S,2R)-2-METHYLAMINO-1-PHENYL-1-PROPANOL HYDROCHLORIDE D-PSEUDOEPHEDRINE HYDROCHLORIDE,PSEUDOEPHEDRINE HYDROCHLORIDE,PSEUDOEPHEDRINE HCL,(+)-1S,2S-PSEUDOEPHEDRINE HCL,(1S,2S)-(+)-PSEUDOEPHEDRINE HYDROCHLORIDE,(+)-PSEUDOEPHEDRINE HYDROCHLORIDE 99+%,pseudoephedrine Hc1,(1S,2S)-2-(METHYLAMINO)-1-PHENYL-1-PROPANOL HYDROCHLORIDE,PSEUDOEPHEDRINE HCl, (+)-1S,2S- SNAPN 1.0mg/ml(P),PSEUDOEPHEDRINE HCl, (+)-1S,2S-(RG),d-(1S,2S)-Pseudoephedrine hydrochloride,Pseudoephedrine hydrochloride (6CI),(1s,2s)-(+)-pseudoephedrine hydrochloride(controlled chemical) Glucosamine 3-Amino-1,2-propanediol 3,4'-DIAMINODIPHENYLMETHANE Iron-dextran Acetaminophen EC 2.6.1.2 Pseudoephedrine Sulfamic acid
  • (+)-ω-Ephedrine, (1S,2S)-2-Methylamino-1-phenyl-1-propanol, d-Isoephedrine, d-Pseudoephedrine
  • (+)-ω-Ephedrine, (+)-Pseudoephedrine, (1S,2S)-2-Methylamino-1-phenyl-1-propanol, d-Isoephedrine, d-Pseudoephedrine
  • d-Pseudoephedrine base
  • (IS,2S)-d-Pseudephedrine Base
  • S,S(+)-PSEUDOEPHEDRINE,1.0MG/MLINMETHANOL
  • (1S,2S)-Ephedrine
  • 6: PN: US20030109453 SEQID: 5 claimed sequence
  • Benzenemethanol, α-[(1S)-1-(methylamino)ethyl]-, (αS)-
  • Benzenemethanol, α-[1-(methylamino)ethyl]-, [S-(R*,R*)]-
  • Pseudoephedrine (6CI)
  • D-PSEUDOEPHEDRINE
  • D-ISOEPHEDRINE
  • (+)-METHYLAMINO-1-PHENYL-PROPAN-1-OL
  • S,S-(+)-PSUEDOEPHEDRINE
  • (+)-PSEUDOEPHEDRINE
  • d-psi-2-Methylamino-1-phenyl-1-propanol
  • D-psi-Ephedrine
  • Isoephedrine
  • l-(+)-pseudoephedrin
  • L-(+)-Pseudoephedrine
  • Pseudoephedrine d-form
  • pseudoephedrine(d)
  • Pseudoephedrine, L-(+)-
  • psi-Ephedrin
  • trans-Ephedrine
  • (+)-psi-ephedrine free base
  • D-Pseudoephedrine (base and/or unspecified salts)
  • ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL, POLYMER-BOUND
  • (1S,2S)-2-METHYLAMINO-1-PHENYL-1-PROPANOL, POLYMER-BOUND
  • (1S,2S)-2-(METHYLAMINO)-1-PHENYLPROPAN-1-OL
  • (1S,2S)-2-METHYLAMINO-1-PHENYL-1-PROPANOL
  • (1S,2S)-(+)-PSEUDOEPHEDRINE
  • (1S,2S)-(+)-PSEUDOEPHEDRINE, POLYMER-BOUND
  • (1S,2S)-PSEUDOEPHEDRINE, POLYMER-BOUND
  • S,S(+)-Pseudoephedrine solution
  • Methamphetamine Solution, 100ppm
  • (+)-pseudoephedrin
  • (+)-psi-ephedrin
  • (alpha-s)-benzenemethano
  • [S-(R*,R*)]-alpha-[1-(methylamino)ethyl]benzenemethanol
  • 2-(Methylamino)-1-phenyl-1-propanol
  • alpha-(1-(methylamino)ethyl)-,(s-(r*,r*))-benzenemethano
  • alpha-[1-(methylamino)ethyl]-,[s-(theta,theta)]-benzenemethano
  • Benzenemethanol, alpha-[1-(methylamino)ethyl]-, [S-(R*,R*)]-
  • Benzenemethanol, alpha-[1-(methylamino)ethyl]-, [S-(R,R)]-
  • Besan
  • d-alpha-[1-(Methylamino)ethyl]benzenemethanol
  • Fisher-(1s,2s)-(+)-pseudoephedrine
  • (1S,2S)-(+)-Pseudoephedine
  • (+/-)-N-Diethylnorpseudoephedrine
  • PSEUDOEPHEDRINE
  • (+)-PSEUDOEPHEDRINE, POLYMER-BOUND
  • (+)-PSI-EPHEDRINE HYDROCHLORIDE, POLYMER-BOUND
  • (+)-PSI-EPHEDRINE
  • Pseudo-efedrine
  • 90-82-4
  • CH3CH3NHCHC6H5OH
  • C6H5CHOHCHNHCH3CH3