Description
Ginsenoside Rh
2 is a steroid glycoside found in plants of the genus
Panax that has diverse biological activities. It inhibits release of β-hexosaminidase from RBL-2H3 cells (IC
50 = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a dose of 25 mg/kg. It inhibits growth of HRA ovarian and BxPC-3 pancreatic cancer cells in a dose-dependent manner.
In vivo, ginsenoside Rh
2 decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma. Ginsenoside Rh
2 also reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury.
Definition
ChEBI: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3
has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.