PHENDIMETRAZINE BITARTRATE

Product Name:
PHENDIMETRAZINE BITARTRATE
CAS No.
50-58-8
Chemical Name:
PHENDIMETRAZINE BITARTRATE
CBNumber:
CB3757053
Molecular Formula:
C20H29NO13
Formula Weight:
491.44
MOL File:
50-58-8.mol
More
Less

PHENDIMETRAZINE BITARTRATE Property

storage temp. 
-20°C
form 
A solid
More
Less

Safety

RIDADR 
UN 1992 6.1(3) / PGIII
HS Code 
2934910000
Toxicity
LD50 intraperitoneal in mouse: 210mg/kg
More
Less

N-Bromosuccinimide Price More Price(1)

Sigma-Aldrich Gold
Product number:
P-126
Product name :
Pyridoxine Impurity Mixture solution
Packaging:
126-1ml
Price:
$634
Updated:
2020/08/18
Buy:
Buy
More
Less

PHENDIMETRAZINE BITARTRATE Chemical Properties,Usage,Production

Originator

Plegine, Ayerst, US ,1961

Uses

Appetite suppressant (systemic).

Manufacturing Process

A mixture of 61 grams 1-phenyl-1-oxo-2-(N-methyl-N-ethanolamino)-propane hydrochloride and 100 cc 98-100% formic acid was refluxed at the boiling point at atmospheric pressure for 45 minutes on an oil bath. Thereafter, the oil bath temperature was increased to 180°C and as much of the excess unreacted formic acid as possible was distilled off. A vigorous evolution of carbon dioxide developed during the distillation, which ceased after approximately 45 additional minutes. The honey-yellow syrup which remained as the distillation residue was worked up by admixing it with about six volumes of water and adjusting the aqueous mixture to alkaline reaction with concentrated sodium hydroxide. An oily phase separated out which was extracted with ether. The ether extract was washed with water and dried over potassium carbonate. The solvent was distilled off and the distillation residue was fractionally distilled in vacuo. The base boils at 132°-133°C at 12 mm. The yield was 93% of theory. Reaction with tartaric acid gave the final product.
The starting material is produced by reacting propiophenone with bromine and then reacting the α-bromopropiophenone produced with 2methylaminomethanol.

brand name

Bontril (Mallinckrodt); Bontril (Valeant); Melfiat (Numark).

Therapeutic Function

Antiobesity

General Description

The optically pure compound phendimetrazine tartrate,(2S,3S)-3,4-dimethyl-2-phenylmorpholine-L-(+)-tartrate(Plegine), is considered an effective anorexiant that is lessabuse prone than amphetamine. The stereochemistry of(+)phendimetrazine is as shown.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

Less

PHENDIMETRAZINE BITARTRATE Suppliers

Global(26)Suppliers
Sinopharm Chemical Reagent Co,Ltd.
Tel:
86-21-63210123
Fax:
86-21-63290778 86-21-63218885
Email:
sj_scrc@sinopharm.com
Country:
China
ProdList:
9848
Advantage:
79
Credit Asia Chemical Co., Ltd.
Tel:
+86 (21) 61124340
Fax:
+86 (21) 6129-4103
Email:
sales02@forever-reagent.com
Country:
China
ProdList:
9781
Advantage:
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel:
Please Email
Fax:
-
Email:
xg01_gj@163.com
Country:
China
ProdList:
9556
Advantage:
50
Amadis Chemical Company Limited
Tel:
0086-571-89925085
Fax:
0086-571-89925065
Email:
sales@amadischem.com
Country:
China
ProdList:
132149
Advantage:
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel:
13382066392
Email:
sales@croteau-lab.com
Country:
CHINA
ProdList:
4888
Advantage:
58
Chongqing Chemdad Co., Ltd
Tel:
+86-13650506873
Email:
sales@chemdad.com
Country:
CHINA
ProdList:
35434
Advantage:
58
Henan Huawen Chemical Co., Ltd
Tel:
0370-2070108-
Fax:
QQ:2712427897
Email:
2712427897@qq.com
Country:
China
ProdList:
8680
Advantage:
58
career henan chemical co
Tel:
+86-371-86658258
Email:
sales@coreychem.com
Country:
CHINA
ProdList:
30039
Advantage:
58

50-58-8, PHENDIMETRAZINE BITARTRATERelated Search:

Bupropion PHENDIMETRAZINE BITARTRATE (S)-2-Methyl-morpholine PHENDIMETRAZINE BITARTRATE (1S,2S)-(+)-N-METHYLPSEUDOEPHEDRINE CIS-3,4-DIMETHYL-2-PHENYLMORPHOLINE 3-methylmorpholine PHENMETRAZINE 3S-3-METHYLMORPHOLINE (S)-2-Dimethylamino-1-phenyletanol, GC 97% 2-DIMETHYLAMINOETHANOL HYDROGEN L-(+)-TARTRATE (1S,2S)-(+)-Pseudoephedrine hydrochloride 2-PHENYLMORPHOLINE
  • 3,4-dimethyl-2-phenyl-morpholin(+)-morpholintartrate(1:1)
  • adipost
  • d-3,4-dimethyl-2-phenyl-morpholinetartrate
  • melfiat
  • metra
  • morpholine,3,4-dimethyl-2-phenyl-,(2s-trans)-,(r-(r*,r*))-2,3-dihydroxybut
  • Pyridoxine Impurity Mixture solution
  • 3,4-Dimethyl-2-phenyl-morpholine bitartrate
  • Phendimetrazine Tartrate CIII (350 mg)
  • PhendiMetrazine Tartrate API
  • phendimetrazinetartrate
  • plegine
  • prelu-2
  • sprx
  • phendimetrazine hydrogen tartrate
  • 3,4-dimethyl-2-phenyl-,tartrate,d-morpholin
  • VEPOHXYIFQMVHW-PVJVQHJQSA-N
  • PHENDIMETRAZINE BITARTRATE
  • 50-58-8
  • C12H17NO2C4H6O6
  • API