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Aclarubicin

Product Name:
Aclarubicin
CAS No.
57576-44-0
Chemical Name:
Aclarubicin
CBNumber:
CB4188966
Molecular Formula:
C42H53NO15
Formula Weight:
811.87
MOL File:
57576-44-0.mol
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Aclarubicin Property

Melting point:
151-153° (dec)
alpha 
D24 -11.5° (c = 1 in methylene chloride)
Boiling point:
756.05°C (rough estimate)
Density 
1.2261 (rough estimate)
refractive index 
1.6220 (estimate)
storage temp. 
2-8°C
pka
6.41±0.70(Predicted)
form 
Yellow powder with orange cast.
color 
Yellow powder
CAS DataBase Reference
57576-44-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
3249
RTECS 
QI9279300
HazardClass 
6.1(a)
PackingGroup 
II
Toxicity
LD50 in mice (mg/kg): 22.6 i.p., 33.7 i.v. (Oki)
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Aclarubicin Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity.

Safety Profile

Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. An eye and subcutaneousirritant. When heated to decomposition it emits toxicfumes of

Enzyme inhibitor

This non-peptidic aclacinomycin antibiotic (FW = 811.88 g/mol; CAS CAS 57576-44-0; Source: strain of Streptomyces galilaeus), also known as aclarubicin, induces DNA strand scission. Target(s): nitric oxide synthase; RNA biosynthesis; DNA polymerase I; RNA polymerase, Escherichia coli; reverse transcriptase, avian myeloblastosis virus; Na+/K+-exchanging ATPase; Ca2+-transporting ATPase; cyclicnucleotide phosphodiesterase; electron transport and oxidative phosphorylation, mitochondrial; DNA helicase; DNA topoisomerase II; 20S proteasome, chymotrypsin-like activity; DNA topoisomerase I; 3'-5' DNA helicase, Plasmodium falciparum.

Aclarubicin Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Aclarubicin Suppliers

Global(69)Suppliers
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
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86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
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China
ProdList:
96815
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76
LGM Pharma
Tel:
1-(800)-881-8210
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615-250-9817
Email:
inquiries@lgmpharma.com
Country:
United States
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1938
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70
Jinan Trio PharmaTech Co., Ltd.
Tel:
+86 (531) 88811783;
Fax:
+86 (531) 55696010 QQ 1762738062
Email:
sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market)
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China
ProdList:
1856
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62
Guangzhou Isun Pharmaceutical Co., Ltd
Tel:
020-39119399-
Fax:
020-39119999
Email:
isunpharm@qq.com
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China
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4485
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55
AdooQ BioScience, LLC
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+1 (866) 930-6790
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ApexBio Technology LLC
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Hangzhou J&H Chemical Co., Ltd.
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0571-87396432-
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0571-87396431
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AdooQ Bioscience CHINA
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025-68650336
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Pharmacodia (Beijing) Co.,Ltd
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57576-44-0, AclarubicinRelated Search:

Bensulfuron methyl CHLOROPHOSPHONAZO III Azithromycin Kresoxim-methyl Methyl bromide Clindamycin 3-Dimethylaminopropylamine Amrubicin Oxytetracycline dihydrate Clarithromycin Gentamicin Minocycline hydrochloride 2-hydroxyaclacinomycin A sulfurmycin B sulfurmycin A ACLARUBICIN HYDROCHLORIDE,Aclarubicin hydrochlride Aclarubicin Methylparaben
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  • antibiotic3082a
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  • ACLARUNBICIN
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, [1R-(1α,2β,4β)]-
  • Jaclacin
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  • Aclacin
  • Aclaplastin
  • Aelacinon
  • MA 144A1:NSC-208734
  • Aclacinomycin(Aclarubicin)
  • Methyl (1R,2R,4S)-4-[4-dimethylamino-5-[4-hydroxy-6-methyl-5-(6-methyl-5-oxo-oxan-2-yl)oxy-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
  • antibiotic77-3082a
  • antibioticma144a
  • antibioticma144a1
  • hyl-5-oxo-2h-pyran-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-
  • ma144-a1
  • methylester,(1r-(1-alpha,2-beta,4-beta))-l-lyxo-hexopyranosyl)oxy)
  • nsc-208734
  • ACM
  • ACLARUBICIN
  • ACLACINOMYCIN A
  • ACLACINOMYCIN A, STREPTOMYCES GALILAEUS
  • ,11-dioxo-4-((2,3,6-trideoxy-4-o-(2,6-dideoxy-4-o-((2r-trans)-tetrahydro-6-met
  • 57576-44-0
  • C42H53NO15
  • Antibiotics
  • Antibiotics A-F
  • Antibiotics A to Z
  • BioChemical
  • Interferes with DNA Synthesis
  • Antibiotics
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Antibiotics by Application
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Mechanism of Action
  • Antitumour
  • ProteasomeInhibitors