Chemical Properties
White Solid
Originator
Topsyn ,Recordati,Italy,1970
Uses
Glucocorticoid; anti-inflammatory.
Uses
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Definition
ChEBI: Fluocinonide is an organic molecular entity.
Indications
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Manufacturing Process
To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is
added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room
temperature for 3 hours. During this period the crystals gradually dissolve and
the clear solution is neutralized with dilute bicarbonate and the acetone
removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95%
alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine
and 1 ml of acetic anhydride is allowed to stand at room temperature for 18
hours. Removal of the reagents in vacuo gives a crystalline residue which
after crystallization from acetone-hexane gives the pure 16α,17α-
isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described
in US Patent 3,197,469.
brand name
Lidex (Medicis); Vanos (Medicis).
Therapeutic Function
Antiinflammatory, Glucocorticoid
Biochem/physiol Actions
Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
