Description
Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both
antiinflammatory and antihyperplasia properties. The compound is recommended for
the treatment of moderate to severe corticosteroid-responsive dermatoses and appears
to be particularly effective in patients with plaque psoriasis. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.
Chemical Properties
White Solid
Originator
Ciba-Geigy (Switzerland)
Uses
Halobetasol propionate is a corticosteroid (cortisone-like medicine or steroid). As an anti-inflammatory drug, halobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. It is also used to treat plaque psoriasis.This medicine is available only with doctor's prescription.
Definition
ChEBI: Ulobetasol propionate is a corticosteroid hormone.
brand name
Ultravate (Westwood-Squibb).
