Description
Oligomycins are macrolides created by
Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F
1F
O-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.
Uses
Oligomycin C is an ATP synthetase and RVD inhibitor.
Uses
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
References
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
