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Folic acid Structure

Folic acid

Chemical Properties

Melting point 250 °C
alpha  20 º (c=1, 0.1N NaOH)
Boiling point 552.35°C (rough estimate)
Density  1.4704 (rough estimate)
refractive index  1.6800 (estimate)
storage temp.  2-8°C
solubility  boiling water: soluble1%
form  Crystalline Powder
pka pKa 2.5 (Uncertain)
color  Yellow to orange
Odor Odorless
PH Range 4
Water Solubility  1.6 mg/L (25 ºC)
Merck  14,4221
BRN  100781
BCS Class 3
Stability Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
InChIKey OVBPIULPVIDEAO-LBPRGKRZSA-N
LogP -0.990 (est)
FDA 21 CFR 172.345; 102.23; 104.20; 310.545
Substances Added to Food (formerly EAFUS) FOLIC ACID
CAS DataBase Reference 59-30-3(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms folate; folic acid
FDA UNII 935E97BOY8
NIST Chemistry Reference Folic acid(59-30-3)
NCI Drug Dictionary folic acid
ATC code B03BB01,B03BB51,V04CX02
EPA Substance Registry System L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)

Safety

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P305+P351+P338
Risk Statements  33-62-68
Safety Statements  24/25
WGK Germany  1
RTECS  LP5425000
8
TSCA  Yes
HS Code  29362900
Hazardous Substances Data 59-30-3(Hazardous Substances Data)
Toxicity A water soluble vitamin required in the diet of mammals. Sulfonamide drugs are selectively toxic to bacteria because they inhibit the incorporation of p-aminobenzoic acid into folic acid, a biosynthetic process in bacteria. Folic acid deficiency adversely affects prenatal development in humans. Dietary supplementation with folic acid dramatically reduces the incidence of neural tube defects in humans. Folic acid deficiency may also contribute to the causes of megaloblastic macrocytic anemia and a consequence of this is that this disease can be induced, as a side effect, when methotrexate, a folic acid antagonist, is used in cancer chemotherapy

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