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Cefpodoxime proxetil

Product Name:
Cefpodoxime proxetil
CAS No.
87239-81-4
Chemical Name:
Cefpodoxime proxetil
CBNumber:
CB5150483
Molecular Formula:
C21H27N5O9S2
Formula Weight:
557.6
MOL File:
87239-81-4.mol
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Cefpodoxime proxetil Property

Melting point:
111-113°C
Density 
1.58±0.1 g/cm3(Predicted)
RTECS 
XI0367370
storage temp. 
-20?C Freezer
solubility 
Soluble in DMSO
form 
neat
pka
8.13±0.60(Predicted)
Sensitive 
Light Sensitive
InChIKey
LTINZAODLRIQIX-FBXRGJNPSA-N
CAS DataBase Reference
87239-81-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-42/43
Safety Statements 
22-26-36/37/39
WGK Germany 
3
HS Code 
30042000
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): >10000, >10000, >2000, >2000 s.c., 3502, 2535, >4000, >4000 i.p.; >8000, >8000, >4000, >4000 orally (Nakao, 1988)
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N-Bromosuccinimide Price More Price(8)

Sigma-Aldrich Gold
Product number:
1098027
Product name :
Cefpodoxime proxetil
Packaging:
350mg
Price:
$352.8
Updated:
2019/12/02
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Buy
Sigma-Aldrich Gold
Product number:
A3987
Product name :
Cefpodoxime proxetil
Packaging:
50mg
Price:
$536
Updated:
2019/12/02
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Buy
Alfa Aesar Gold
Product number:
J66061
Product name :
Cefpodoxime proxetil, 96%
Packaging:
1g
Price:
$243
Updated:
2019/12/02
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Buy
Cayman Chemical Gold
Product number:
25412
Product name :
Cefpodoxime-d3
Purity:
≥99% deuterated forms (d1-d3)
Packaging:
1mg
Price:
$226
Updated:
2019/12/02
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Buy
Cayman Chemical Gold
Product number:
25412
Product name :
Cefpodoxime-d3
Purity:
≥99% deuterated forms (d1-d3)
Packaging:
500μg
Price:
$125
Updated:
2018/11/19
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Buy
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Cefpodoxime proxetil Chemical Properties,Usage,Production

Brand Name(s) in US

Simplicef (veterinary drug)
Vantin (human drug)

Description

Cefpodoxime proxetil is an orally active, broad-spectrum cephalosporin especially useful in the treatment of bacterial infections in children. It is a prodrug converted by esterases in the GI walls to cefpodoxime, which reportedly has a bacteriostatic spectrum comparable to injectable third-generation cephem antibiotics.

Chemical Properties

Pale Yellow Solid

Originator

Sankyo (Japan)

Uses

A metabolite of Cefpodoxime Proxetil. An antibacterial.

Uses

An antibacterial. A broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime

Definition

ChEBI: The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pha yngitis, and sinusitis.

brand name

Vantin (Pharmacia & Upjohn);Banan.

Clinical Use

Cefpodoxime proxetil (Vantin) is the isopropyloxycarbonylethylester of the third-generation cephalosporincefpodoxime. This orally active prodrug derivative is hydrolyzedby esterases in the intestinal wall and in theplasma to provide cefpodoxime. Tablets and a powder forthe preparation of an aqueous suspension for oral pediatricadministration are available. The oral bioavailability of cefpodoximefrom the proxetil is estimated to be about 50%.Administration of the prodrug with food enhances its absorption.The plasma half-life is 2.2 hours, which permitsadministration on a twice-daily schedule.
Cefpodoxime is a broad-spectrum cephalosporin withuseful activity against a relatively wide range of Grampositiveand Gram-negative bacteria. It is also resistant tomany β-lactamases. Its spectrum of activity includes S.pneumoniae, Streptococcus pyogenes, S. aureus, H. influenzae,M. catarrhalis, and Neisseria spp. Cefpodoxime is alsoactive against members of the Enterobacteriaceae family,including E. coli, K. pneumoniae, and P. mirabilis. It thusfinds use in the treatment of upper and lower respiratory infections,such as pharyngitis, bronchitis, otitis media, andcommunity-acquired pneumonia. It is also useful for thetreatment of uncomplicated gonorrhea.

Veterinary Drugs and Treatments

In dogs, cefpodoxime is indicated for the treatment of skin infections caused by Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis, E. coli, Proteus mirabilis, and Pasteurella multocida. Although not currently approved for cats, it may also be useful as well.

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Cefpodoxime proxetil Suppliers

Global(158)Suppliers
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD
Fax:
020-87659730
Email:
dylan@gzbr.com.cn;cdm@gzbr.com.cn;goldg@gzbr.com.cn
Country:
China
ProdList:
202
Advantage:
58
Wellman Pharmaceutical Group Limited
Tel:
027-83778875-
Fax:
027-83991220
Email:
15807197853@163.com;
Country:
China
ProdList:
3337
Advantage:
58
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Fax:
86-21-50328109
Email:
3bsc@sina.com
Country:
China
ProdList:
15881
Advantage:
69
Pure Chemistry Scientific Inc.
Tel:
001-857-928-2050 or 1-888-588-9418
Fax:
001-617-206-9595
Email:
sales@chemreagents.com
Country:
United States
ProdList:
9919
Advantage:
62
LGM Pharma
Tel:
1-(800)-881-8210
Fax:
615-250-9817
Email:
inquiries@lgmpharma.com
Country:
United States
ProdList:
1939
Advantage:
70
Nanjing Chemlin Chemical Co., Ltd
Tel:
025-83697070
Fax:
+86-25-83453306
Email:
info@chemlin.com.cn
Country:
China
ProdList:
19992
Advantage:
64
Chemsky(shanghai)International Co.,Ltd.
Tel:
021-50135380
Email:
shchemsky@sina.com
Country:
China
ProdList:
32359
Advantage:
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel:
0712-2580635- ;0712-2580635
Fax:
QQ: 1791901229
Email:
1791901229@qq.com;1791901229@qq.com;
Country:
China
ProdList:
9007
Advantage:
52

87239-81-4, Cefpodoxime proxetil Related Search:

2-Cyanoacetamide Thioacetamide Ethylparaben Diethyl ether Ethanol Acetamide Ethyl acrylate N,N-Dimethylacetamide Cefdaloxime 7-AMCA METHYL-2-N-ACETYL CROTANOATE TRIMETHYLAMMONIUM FORMIATE Hydroxymethyl-7-Aminocephalosporanic acid Methyl N,N-dimethylaminoacrylate Cefpodoxime proxetil 2-Phenylacetamide DIACETAMIDE Ethylbenzene
  • Cefpodoxime, Free Acid (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, [6R-[6α,7β(Z)]]-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-
  • Antibiotic CS 807
  • Cephpodoxime proxetil
  • CS 807 (pharmaceutical)
  • RU 51807
  • Cefpodoxime Proxetil, Vantin, (RS)-1(isopropoxycarbonyloxy)ethyI (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-{(Z)methoxyimino}acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • Cefpodoxime-d3, Free Acid
  • Orelox:Otreon
  • (6R,6β)-7α-[[(2-Aminothiazol-4-yl)[(Z)-(methoxy)imino]acetyl]amino]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(isopropoxycarbonyloxy)ethyl ester
  • Cefpodoxime Proxetil (350 mg)
  • A spore anchors wo ester
  • (6R,7R)-7-[(2Z)-2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-3-(MethoxyMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino-d3)acetyl]aMino]-3-(MethoxyMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • CefpodoxiMe-d3
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-3-(MethoxyMethyl)-8-oxo-,1-[[(1-Methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-
  • Cefpodoxime proxetil for peak identification
  • Cefpodoxime proxetil for impurity H identification
  • cefpodoxime proxetil IMP IMP
  • R-3763
  • Cefpodoxime Proxetil Impurity
  • Cefpodoxime Proxetil (Mixture of Diastereomers)
  • 7-[[2-methoxyimino-2-(2-methyl-4-thiazolyl)-1-oxoethyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-[oxo(propan-2-yloxy)methoxy]ethyl ester
  • (RS)-1(ISOPROPOXYCARBONYLOXY)ETHYL (+)-(6R,7R)-7-[2-(2-AMINO-4-THIAZOLYL)-2-[(Z)METHOXYIMINO]ACETAMIDO]-3-METHOXYMETHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE
  • ORELOX
  • OTREON
  • U-76252
  • U-76253
  • VANTIN
  • (6r-(6-alpha,7-beta(z)))-bonyl)oxy)ethyleste
  • 1-(((1-methylethoxy)car
  • (+)-(6R,7R)-7-[2-(2-AMINO-4-THIAZOLYL)-2-[(Z)METHOXYIMINO]ACETAMIDO]-3-METHOXYMETHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE
  • BANAN
  • CS-807
  • CEFODOX
  • CEFPODOXIME PROXETIL
  • Cefpodoxime Proxetil JPFa
  • CefpodoximeProxet
  • Cefopodoximeproxetil
  • JP,USP
  • CS-807, U-76252, Banan, Cefodox, Orelox, Otreon, Vantin
  • (RS)-1-(Isopropoxycarbonyloxy)ethyl (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-[(Z)-(methoxyimino]acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 87239-81-4
  • C15H14D3N5O6S2
  • C21H27N5O9S2
  • C15H17N5O6S2
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotope Labeled Compounds
  • Metabolites & Impurities
  • Cefpodoxime
Brand Name(s) in US