Chemical Properties
Crystalline Solid
Uses
Scopoletin can be used for cosmetics, topical formulations, and foods.
Uses
Scopoletin is the aglucone of Scopolin. Used for cosmetics, topical formulations, and foods. Dyes and metabolites.
Definition
ChEBI: A hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 3083, 1962
DOI: 10.1021/jo01056a023
General Description
Scopoletin is a coumarin compound and pharmacologically active chemical that is found in various plant species.
Biochem/physiol Actions
Scopoletin significantly increases activity of lipoprotein lipase in adipocytes by promoting transcription of the LPL gene. It also partially reverses inhibition of LPL by TNF-α.
Purification Methods
Crystallise it from water, acetic acid or *C6H6/MeOH. It is dimorphic with a second m at 193-195o. It sublimes at 120-130o/12mm. [Beilstein 18 H 99, 18 I 348, 18 II 68, 18 III/IV 1323, 18/3 V 203.]
