Description
Hydrazine, anhydrous appears as a colorless, fuming oily liquid with an ammonia-like odor. Flash point 99°F. Explodes during distillation if traces of air are present. Toxic by inhalation and by skin absorption. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.
Chemical Properties
White moist crystals and chunks
Uses
Acethydrazide can be used in the synthesis of (
E)-
N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.
Uses
Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.
Uses
Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.
Definition
ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.
Purification Methods
Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]