ChemicalBook > CAS DataBase List > DL-α-Tocopherol

DL-α-Tocopherol

Product Name:
DL-α-Tocopherol
CAS No.
10191-41-0
Chemical Name:
DL-α-Tocopherol
CBNumber:
CB5275357
Molecular Formula:
C29H50O2
Formula Weight:
430.71
MOL File:
10191-41-0.mol
More
Less

DL-α-Tocopherol Property

Melting point:
2-4°C
alpha 
[α]D20 - 0.02 - +0.02゜ (neat)
Boiling point:
200-220°C 0,1mm
Density 
0.950 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.506
Flash point:
240°C
storage temp. 
2-8°C
solubility 
H2O: insoluble
form 
Pale yellow oil
pka
11.40±0.40(Predicted)
Water Solubility 
Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive 
Light Sensitive
Merck 
14,9495
BRN 
94012
InChIKey
GVJHHUAWPYXKBD-IEOSBIPESA-N
CAS DataBase Reference
10191-41-0(CAS DataBase Reference)
EPA Substance Registry System
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- (10191-41-0)
More
Less

Safety

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-37/39-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
RTECS 
GA8746000
8-10-23
TSCA 
Yes
HS Code 
29362800
More
Less

N-Bromosuccinimide Price More Price(24)

Sigma-Aldrich Gold
Product number:
258024
Product name :
α-Tocopherol
Purity:
≥95.5%
Packaging:
5g
Price:
$13
Updated:
2020/08/18
Buy:
Buy
Sigma-Aldrich Gold
Product number:
1667600
Product name :
Alpha Tocopherol
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
250mg
Price:
$371
Updated:
2020/08/18
Buy:
Buy
TCI Chemical Gold
Product number:
T0251
Product name :
DL-α-Tocopherol
Purity:
>96.0%(GC)
Packaging:
25g
Price:
$25
Updated:
2020/06/24
Buy:
Buy
TCI Chemical Gold
Product number:
T0251
Product name :
DL-α-Tocopherol
Purity:
>96.0%(GC)
Packaging:
250g
Price:
$96
Updated:
2020/06/24
Buy:
Buy
Alfa Aesar Gold
Product number:
A17039
Product name :
DL-alpha-Tocopherol, 97+%
Packaging:
50g
Price:
$46.7
Updated:
2020/06/24
Buy:
Buy
More
Less

DL-α-Tocopherol Chemical Properties,Usage,Production

Chemical Properties

1mg = 1.1 IU

Chemical Properties

Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.

Uses

dl-α-Tocopherol is the racemic analog of α-Tocopherol (T526125), the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils. dl-α-Tocopherol is an antioxidant that protects cell membrane lipids from oxidative damage.

Production Methods

Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.

Pharmaceutical Applications

Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants.
Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate.
Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations.
d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.

Safety

Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used.
Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis.
The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet.
The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.

storage

Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants.
Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.

Purification Methods

Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]

Incompatibilities

Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

Less

DL-α-Tocopherol Suppliers

Global(272)Suppliers
Shanghai Tauto Biotech Co., Ltd
Tel:
021-51320588
Fax:
0086-21-51320502
Email:
tauto@tautobiotech.com
Country:
China
ProdList:
3582
Advantage:
66
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96504
Advantage:
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Fax:
86-21-61259102
Email:
sh@meryer.com
Country:
China
ProdList:
40268
Advantage:
62
future industrial shanghai co., ltd
Tel:
400-0066-400;021-60496031
Fax:
021-55660885
Email:
sales@jonln.com;sales@jonln.com
Country:
China
ProdList:
2000
Advantage:
65
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Fax:
021-67582001/03/05
Email:
saleschina@alfa-asia.com
Country:
China
ProdList:
30163
Advantage:
84
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Fax:
021-67121385
Email:
Sales-CN@TCIchemicals.com
Country:
China
ProdList:
24555
Advantage:
81
Beijing dtftchem Technology Co., Ltd.
Tel:
010-60275820-
Fax:
010-60270825
Email:
dtftchem@sina.com;
Country:
China
ProdList:
1403
Advantage:
62
BeiJing Hwrk Chemicals Limted
Tel:
0757-86311057-
Fax:
0757-86311057
Email:
kennyrong@hwrkchemical.com
Country:
China
ProdList:
18708
Advantage:
55
Energy Chemical
Tel:
021-58432009
Fax:
021-58436166-800
Email:
sales8178@energy-chemical.com
Country:
China
ProdList:
44026
Advantage:
61

10191-41-0, DL-α-TocopherolRelated Search:

VITAMIN B1 MONONITRATE,VITAMIN B1 NITRATE DL-α-Tocopherol DL-ALPHA-TOCOPHEROL ACETATE,DL-ALPHA TOCOPHEROL, 100MG, NEAT,DL-ALPHA-TOCOPHEROL ACETATE, PH EUR,DL-ALPHA-TOCOPHEROL ACETATE, 100MG, NEAT,DL-ALPHA-TOCOPHEROL ACETATE 50% Fattyalkyl dimethyl amine Vitamin AD3 Methyl tetrahydrophthalic anhydride VITAMIN B2 Diethylstilbestrol Tocopherol alkylolamide(s) DL-ALPHA-TOCOPHEROL ACETATE VE(mixed tocopherols) Vitamin E D-alpha-Tocopheryl acetate MULTIVITAMIN ALPHA-TOCOPHEROL Vitamin B12 Methylhexahydrophthalic anhydride
  • ALL-RAC-ALPHA-TOCOPHEROL
  • (+/-)-ALPHA-TOCOPHEROL
  • (+/-)-ALPHA-TOCOFEROL
  • ALPHA-TOCOPHEROLUM
  • ALPHA-DL-TOCOPHEROL
  • 5,7,8-TRIMETHYLTOCOL
  • A-TOCOPHEROL
  • IRGANOX E 201
  • DL-TOCOPHEROL
  • DL-VITAMIN E
  • DL-VITAMIN E ALCOHOL
  • DL-PROFECUNDIN
  • DL-PHYTOGERMINE
  • DL-ALL-RAC-ALPHA-TOCOPHEROL
  • DL-ALPHA-TOCOPHEROL
  • DL-ALPHA TOCOPHERYL ACETATE 500
  • D, L-A-TOCOPHEROL
  • DL-5,7,8-TRIMETHYLTOCOL
  • DL-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL
  • RAC-ALPHA-TOCOPHEROL
  • ecyl)-
  • ephanyl
  • TOCOPHEROL, ALPHA-DL-
  • VITAMIN E (DL-FORM)
  • 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromano
  • DL-ALPHA-TOCOPHEROL, PH EUR
  • VITAMIN E (MIXED TOCOPHEROL) NATURAL 50%
  • VITAMIN E OIL, 96-102% USP
  • ALPHA TOCOPHEROL (VITAMIN E ALCOHOL) USP(CRM STANDARD)
  • (±)-α-Tocopherol,DL-all-rac-α-Tocopherol, VitaminE
  • DL-all-rac-α-Tocopherol
  • Vitamin E 100mg [10191-41-0]
  • Alpha Tocopherol (250 mg) (Vitamin E Alcohol)
  • (§1)-alpha-Tocopherol, synthetic, 95%
  • VitaMin E Alcohol
  • 1-benzyl-5-chloro-1
  • 4-tetrahydro-1
  • 5-TriMethyl-1H-pyrazol-4-yl)ethanol
  • 2-(1-Fluoronaphthalen-4-yl)-4
  • 2-benzyl-5-chloro-1
  • 4-tetrahydro-2
  • 2-Cyclopropyl-4
  • 2-dioxaborinan-2-yl)pyridine
  • 2-dioxaborinan-2-yl)benzonitrile
  • 4-BroMo-2-(5
  • 8-broMo-4-chloro-2-(Methylthio)pyrazolo[1
  • N-(3-DiMethylaMinopropyl)-3-(4
  • 4-Tetrahydroisoquinoline-3-carboxylicacid
  • tert-Butyl-N-Methyl-N-[4-(4
  • VitaMin E / dl-α-Tocopherol
  • All-rac-a-Tocopherol, FCC
  • VitaMin E, 1 Mg = 1.1 IU, USP, EP, BP, JP
  • (+/-)-alpha-Tocopherol, 95%, synthetic
  • 2-(4-(benzyloxy)-2-chlorophenyl)-5
  • 2-Methyl-6-(4
  • 2-Methyl-7-(4
  • 2-Methyl-8-(4
  • 2-dioxaborolan-2-yl)pyridin-2-ol