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Methylaminoformyl chloride

Product Name:
Methylaminoformyl chloride
CAS No.
6452-47-7
Chemical Name:
Methylaminoformyl chloride
CBNumber:
CB5512113
Molecular Formula:
C2H4ClNO
Formula Weight:
93.51
MOL File:
6452-47-7.mol
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Methylaminoformyl chloride Property

Melting point:
45°C
Boiling point:
93°C (dec.)
Density 
1.185±0.06 g/cm3(Predicted)
pka
10.67±0.46(Predicted)
CAS DataBase Reference
6452-47-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Methylaminoformyl chloride Chemical Properties,Usage,Production

Description

Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Uses

Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Preparation

Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009

Methylaminoformyl chloride Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Methylaminoformyl chloride Suppliers

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Shanghai Yichang Chemical Co., Ltd.
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6452-47-7, Methylaminoformyl chlorideRelated Search:

Diphenylcarbamyl chloride Sodium chloride Potassium chloride 2-Fluorobenzoyl chloride Methylene Chloride 4-tert-Butylbenzoyl chloride Methanesulfonyl chloride Calcium chloride Benzoyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile Choline chloride Ammonium chloride Acetyl chloride Pivaloyl chloride Methylaminoformyl chloride p-Toluoyl chloride Polyvinyl chloride 4-Nitrobenzoyl chloride
  • METHYLCARBAMOYLCHLORIDE
  • METHYLAMINOFORMYL CHLORIDE
  • n-methylaminoformyl chloride
  • Methylcarbamic chloride
  • N-Methylchloroformamide
  • Methylcarbamic acid chloride
  • N-(Chloroformyl)methylamine
  • N-Methylcarbamoyl chloride
  • CarbaMic chloride,Methyl- (9CI)
  • Carbamic chloride, N-methyl-
  • Carbamic chloride, methyl-
  • 6452-47-7
  • CH3NHCOCl
  • Agrochemicals
Description Uses Preparation