Chemical Properties
colorless or clear slightly yellow liquid. Boiling point 284-287°C, 180-181°C (4.13kPa). Relative density 1.062, refractive index 1.5785. soluble in ethanol, ether, insoluble in water.
Uses
4-Benzylpyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals.It is the key raw material for the synthesis of Ifenprodil hemitartrate.
Preparation
4-Benzylpyridine is synthesized from benzyl chloride and pyridine.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 1889, 1962
DOI: 10.1021/jo01052a509
Safety Profile
Poison by ingestion andintravenous routes. A flammable material. Incompatible with oxidizers. When heated to decomposition it emitstoxic fumes of NOx.
Purification Methods
Dry it with NaOH for several days, then distil it from CaO under reduced pressure, and redistil the middle fraction. [Beilstein 20/7 V 561.]
