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Zolpidem

Product Name:
Zolpidem
CAS No.
82626-48-0
Chemical Name:
Zolpidem
CBNumber:
CB6345253
Molecular Formula:
C19H21N3O
Formula Weight:
307.39
MOL File:
82626-48-0.mol
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Zolpidem Property

Melting point:
189-191°C
Density 
1.12±0.1 g/cm3(Predicted)
Flash point:
9℃
storage temp. 
Store at RT
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
pka
6.2(at 25℃)
form 
solid
color 
white
Water Solubility 
<10mg/L(room temperature)
CAS DataBase Reference
82626-48-0(CAS DataBase Reference)
NIST Chemistry Reference
Zolpidem(82626-48-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
NJ5109750
HS Code 
2933996500
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N-Bromosuccinimide Price More Price(5)

Sigma-Aldrich Gold
Product number:
Z103
Product name :
Zolpidem
Purity:
≥98% (HPLC), solid
Packaging:
5mg
Price:
$160
Updated:
2019/12/02
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Buy
Sigma-Aldrich Gold
Product number:
Z103
Product name :
Zolpidem
Purity:
≥98% (HPLC), solid
Packaging:
25mg
Price:
$548
Updated:
2019/12/02
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Buy
Cayman Chemical Gold
Product number:
20648
Product name :
Zolpidem (CRM)
Packaging:
1mg
Price:
$25
Updated:
2020/06/24
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Cayman Chemical Gold
Product number:
15792
Product name :
Zolpidem
Packaging:
5mg
Price:
$100
Updated:
2020/06/24
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Sigma-Aldrich Gold
Product number:
Z-017
Product name :
Zolpidem solution
Packaging:
017-1ml
Price:
$26.9
Updated:
2019/12/02
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Zolpidem Chemical Properties,Usage,Production

Description

Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.

Chemical Properties

Off-White Solid

Originator

Synthelabo (France)

Uses

A selective benzodiazepine receptor agonist not related chemically to benzodiazepines

Uses

A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).

Definition

ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.

brand name

Ambien (Sanofi Aventis);Stilnox.

General Description

Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.

Zolpidem Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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82626-48-0, ZolpidemRelated Search:

2-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE 2-(6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE N,N-DIMETHYL-D6-ACETAMIDE 2-(2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE N,N-DIMETHYL-D6-FORMAMIDE Imidazo(1,2-a)pyridine-3-acetamide,2-methyl- 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE 2-(2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE Imidazo[1,2-a]pyridine-3-ethanamine (9CI) AMBIEN Zolpidem N,N-Dimethylacetamide PHRIDINE ACETATE 4-Methylpyridine Pyridine 1-Methylimidazole 2,6-Lutidine ZOLPIDEM HEMITARTRATE,ZOLPIDEM TARTRATE,Zolpidem Tartrate Tablet,ZOLPIDEM TARTRATE EP C IV
  • EDLUAR; SL 80-0750; SL 800750
  • 2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
  • N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
  • N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
  • SL-80.0750
  • N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE
  • N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE HEMITARTRATE
  • N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIMIDINE-3-ACETAMIDE
  • ZOLPIDEM
  • ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
  • 6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
  • N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
  • 6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
  • 2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-
  • Ivadal
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-α]pyridine-3-acetamide
  • Niotal
  • SL-80.0750-23N
  • Stilnoct:Stilnox
  • Zoipidem
  • N,N-Dimethyl-2-[6-methyl-2-p-tolylimidazo[1,2-a]pyridine-3-yl]acetamide
  • Zolpidem tatrate
  • 2-(1,2,6-Trimethyl-1H-indol-3-yl)ethylamine
  • N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]ethanamide
  • Zolpidem CIV (10 mg)
  • N,N,6-triMethyl-2-(4-Methylphenyl)iMidazo[1,2-a]-pyrid
  • Edluar
  • Imidazo[1,2-a]pyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-
  • Zolpidem solution
  • Zolpidem (CRM)
  • CS-1159
  • Zolpideman(SL 800750)
  • 82626-48-0
  • C19H21N3O
  • Pyridines derivates
  • (intermediate of zolpidem)
  • Zolpidem
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotopically Labeled Pharmaceutical Reference Standard