ChemicalBook > CAS DataBase List > 1,9-Pyrazoloanthrone

1,9-Pyrazoloanthrone

Product Name:
1,9-Pyrazoloanthrone
CAS No.
129-56-6
Chemical Name:
1,9-Pyrazoloanthrone
CBNumber:
CB6354608
Molecular Formula:
C14H8N2O
Formula Weight:
220.23
MOL File:
129-56-6.mol
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1,9-Pyrazoloanthrone Property

Melting point:
281~282℃
Boiling point:
361.16°C (rough estimate)
Density 
1.1702 (rough estimate)
refractive index 
1.5910 (estimate)
storage temp. 
2-8°C
solubility 
H2O: insoluble
pka
11.75±0.20(Predicted)
form 
Yellowish orange solid
color 
yellow
InChIKey
ACPOUJIDANTYHO-UHFFFAOYSA-N
CAS DataBase Reference
129-56-6(CAS DataBase Reference)
EPA Substance Registry System
Anthra[1,9-cd]pyrazol-6(2H)-one (129-56-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
CB4585000
TSCA 
Yes
HS Code 
29339900
Toxicity
LD50 ivn-mus: 178 mg/kg CSLNX* NX#00640
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N-Bromosuccinimide Price More Price(10)

Sigma-Aldrich Gold
Product number:
420119
Product name :
JNK Inhibitor II
Packaging:
5mg
Price:
$75.2
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
420119
Product name :
JNK Inhibitor II
Packaging:
25mg
Price:
$228
Updated:
2019/12/02
Buy:
Buy
TCI Chemical Gold
Product number:
A2548
Product name :
Anthra[1,9-cd]pyrazol-6(2H)-one
Purity:
>98.0%(HPLC)
Packaging:
25mg
Price:
$42
Updated:
2020/06/24
Buy:
Buy
Alfa Aesar Gold
Product number:
J67272
Product name :
SP600125
Purity:
99%
Packaging:
50mg
Price:
$92.4
Updated:
2020/06/24
Buy:
Buy
Alfa Aesar Gold
Product number:
J67272
Product name :
SP600125
Purity:
99%
Packaging:
100mg
Price:
$161
Updated:
2020/06/24
Buy:
Buy
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1,9-Pyrazoloanthrone Chemical Properties,Usage,Production

Uses

A broad-spectrum serine/threonine kinase inhibitor of JNK with an IC50 range from 40 to 90 nM.

Definition

ChEBI: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.

Biological Activity

Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40-90 nM) with negligible activity at ERK2, p38 β and a range of enzymes (IC 50 > 10 μ M). Active in vivo . Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™ .

Safety Profile

Poison by intravenous route.When heated to decomposition it emits toxic fumes ofNOx.

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1,9-Pyrazoloanthrone Suppliers

Global(143)Suppliers
Shijiazhuang XinZhaoYang Chemical Technology Co., Ltd.
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025-68650336
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jkinfo@jkchemical.com;market6@jkchemical.com
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Chembest Research Laboratories Limited
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021-58180499
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sales@BioChemBest.com
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TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
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Ascent Scientific
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129-56-6, 1,9-PyrazoloanthroneRelated Search:

Sulfisoxazole Teloxantrone Furosemide Phthalylsulfathiazole 2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE Sulfamethoxazole 4-Nitrobenzenesulfonamide N,N'-DIACETYLSULFANILAMIDE SULFAMOXOL N1-METHYL-1,9-PYRAZOLOANTHRONE,N'-METHYL-1,9-PYRAZOLOANTHRONE Sulfadiazine 4-Amino-6-chlorobenzene-1,3-disulfonamide SULFISOMIDINE 1,9-Pyrazoloanthrone 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Mefenpyr-diethyl Zolpidem tartrate Pyraclostrobin
  • CS-548
  • JNK Inhibitor II - CAS 129-56-6 - Calbiochem
  • 1 9-PYRAZOLEANTHRONE
  • 1,9-PYRAZOLOANTHRONE
  • JNK INHIBITOR II
  • ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE
  • ANTHRA-1,9-PYRAZOL-6-NONE
  • ANTHRAPYRAZOLONE
  • 3H-naphtho[2,3-f]indazol-3-one
  • 1,9-Pyrazoloanthrone, Anthrapyrazolone
  • JNKII
  • SP 600125 - NSC 75890
  • SP 600125;SP-600125;NSC75890
  • Nsc75890
  • Wln: T C6665 1A p iv omnj
  • SP600125 >99%
  • JNK Inhibitor II, 1,9-Pyrazoloanthrone
  • Dibenzo[cd,g]indazol-6(2H)-one
  • 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
  • InSolution&trade
  • SP 600125, >=98%
  • c.i.70300
  • pyrazolanthrone
  • SAPK INHIBITOR I
  • SAPK INHIBITOR II
  • SP600125
  • TIMTEC-BB SBB000595
  • 2H-DIBENZO[CD,G]INDAZOL-6-ONE
  • 129-56-6
  • C14H8N2O
  • C14H9N2O
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • KETONE
  • Kinase/Phosphatase Biology
  • c-Jun N-Terminal Kinase (JNK)
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase
  • Signalling
  • Inhibitor
  • Other APIs
  • MAPK
  • Inhibitors