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Colchicine Structure

Colchicine

Chemical Properties

Melting point 150-160 °C (dec.)(lit.)
alpha  -250 º (c=1, alcohol)
Boiling point 522.37°C (rough estimate)
Density  1.2770 (rough estimate)
refractive index  1.5614 (estimate)
storage temp.  2-8°C
solubility  H2O: 10 mg/mL
pka 12.36(at 20℃)
form  powder
color  white to yellow with a green cast
Water Solubility  45 g/L (20 ºC)
Sensitive  Light Sensitive
Merck  14,2471
BRN  2228813
BCS Class 3
Stability Stable. Light sensitive. Incompatible with strong oxidizing agents.
InChIKey IAKHMKGGTNLKSZ-INIZCTEOSA-N
LogP 1.300
CAS DataBase Reference 64-86-8(CAS DataBase Reference)
EWG's Food Scores 4-7
NCI Dictionary of Cancer Terms colchicine
FDA UNII SML2Y3J35T
NCI Drug Dictionary colchicine
ATC code M04AC01
Proposition 65 List Colchicine
NIST Chemistry Reference Colchicine(64-86-8)
EPA Substance Registry System Colchicine (64-86-8)

Safety

Symbol(GHS)
Signal wordDanger
Hazard statements H300-H340
Precautionary statements P202-P264-P270-P280-P301+P310-P405
Hazard Codes  T+,T,Xi
Risk Statements  26/28-41-46
Safety Statements  13-45-36/37/39-28-26-53
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  GH0700000
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29399990
Hazardous Substances Data 64-86-8(Hazardous Substances Data)
Toxicity LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)
NFPA 704:
1
3 0

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