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Prednisone

Product Name:
Prednisone
CAS No.
53-03-2
Chemical Name:
Prednisone
CBNumber:
CB6716222
Molecular Formula:
C21H26O5
Formula Weight:
358.43
MOL File:
53-03-2.mol
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Prednisone Property

Melting point:
236-238 °C(lit.)
alpha 
169 º (c=0.5, dioxane)
Boiling point:
410.86°C (rough estimate)
Density 
1.1121 (rough estimate)
refractive index 
170 ° (C=0.5, Dioxane)
Flash point:
>200℃
storage temp. 
Refrigerator
solubility 
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
pka
12.36±0.60(Predicted)
Water Solubility 
115mg/L(25 ºC)
Merck 
7722
BRN 
2065301
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
53-03-2(CAS DataBase Reference)
NIST Chemistry Reference
Prednisone(53-03-2)
EPA Substance Registry System
Prednisone (53-03-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
Safety Statements 
36/37/39-45-26-16
Hazardous Substances Data
53-03-2(Hazardous Substances Data)
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N-Bromosuccinimide Price More Price(4)

Cayman Chemical Gold
Product number:
20677
Product name :
Prednisone
Purity:
≥98%
Packaging:
1g
Price:
$25
Updated:
2018/11/19
Buy:
Buy
Cayman Chemical Gold
Product number:
20677
Product name :
Prednisone
Purity:
≥98%
Packaging:
5g
Price:
$113
Updated:
2018/11/19
Buy:
Buy
Cayman Chemical Gold
Product number:
20677
Product name :
Prednisone
Purity:
≥98%
Packaging:
10g
Price:
$200
Updated:
2018/11/19
Buy:
Buy
Cayman Chemical Gold
Product number:
20677
Product name :
Prednisone
Purity:
≥98%
Packaging:
25g
Price:
$375
Updated:
2019/12/02
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Buy
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Prednisone Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Adrenocortical steroid. Glucocorticoid, antiinflammatory.

Uses

Downregulates TNF-α production and NF-κB expression

Definition

ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.

brand name

Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).

General Description

Odorless white crystalline powder.

General Description

Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.

Air & Water Reactions

Very slightly water soluble .

Hazard

Questionable carcinogen.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.

Purification Methods

Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

Prednisone Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Prednisone Suppliers

Global(266)Suppliers
Shanghai Boyle Chemical Co., Ltd.
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Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
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53-03-2, PrednisoneRelated Search:

Prednisone pivalate PREDNISONE SODIUM PHOSPHATE Hydrocortisone sodium succinate 1,4-PREGNADIEN-6-ALPHA-METHYL-17,21-DIOL-3,11,20-TRIONE PREDNISONE HEMISUCCINATE:HISTAMINE chloroprednisone 21-acetate PREDNISONE 21-HEMISUCCINATE,PREDNISONE HEMISUCCINATE 1,4-PREGNADIEN-16-BETA-METHYL-17,21-DIOL-3,11,20-TRIONE 21-ACETATE PREDNISONE, [1,2-3H] 1,4-PREGNADIEN-6-ALPHA-METHYL-17,21-DIOL-3,11,20-TRIONE 21-HEMISUCCINATE Pregna-1,4-diene-3,11,20-trione, 17-hydroxy-21-(phosphonooxy)-, disodium salt Prednisone prednisone 21-acetate,PREDNISONE ACETATE Fludrocortisone Hydrocortisone Hydrocortisone-17-butyrate CORTISONE Prednisolone
  • Prednisolone EP Impurity B
  • 1,2-Dehydrocortisone
  • 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione
  • 11,20-trione,17,21-dihydroxy-pregna-4-diene-3
  • 11,20-trione,17,21-hydroxy-pregna-4-diene-3
  • Ancortone
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  • delta-E
  • Deltasone
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  • Deltison
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  • Deltra
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  • Encorton
  • Encortone
  • Enkorton
  • Hostacortin
  • In-Sone
  • Juvason
  • Lisacort
  • meburamide
  • Metacortandracin
  • Meticorten
  • NCI-C04897
  • nci-co4897
  • NSC 10023
  • nsc10023
  • Orasone
  • Paracort
  • Precort
  • Prednicen-M
  • Prednilonga
  • Prednizon
  • 1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • (8S,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-7,8,9,10,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,11-DIONE
  • Prednisone,98%
  • PREDNISONE, PH EUR
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  • PREDNISONE,ANHYDROUS,MICRONIZED,USP
  • PREDNISONE,ANHYDROUS,POWDER,USP
  • MOPP
  • 1,4-Pregnadiene-17a,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone, Prednisonum
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
  • Apo-Prednisone
  • Ancotone
  • 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
  • Prednisolone Impurity 2(Prednisolone EP Impurity B)
  • Cotone
  • Dacortin
  • Decortancyl
  • Decortin