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Papaverine hydrochloride

Product Name:
Papaverine hydrochloride
CAS No.
61-25-6
Chemical Name:
Papaverine hydrochloride
CBNumber:
CB7689772
Molecular Formula:
C20H22ClNO4
Formula Weight:
375.85
MOL File:
61-25-6.mol
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Papaverine hydrochloride Property

Melting point:
226°C (dec.)
storage temp. 
Amber Vial, Refrigerator
solubility 
H2O: 25 mg/mL
form 
powder
color 
white
PH
pH (20g/l, 25℃) : 3.0~4.0
Water Solubility 
freely soluble
Sensitive 
Light Sensitive
Merck 
14,7019
BRN 
3921435
Stability:
Stable, but may be light sensitive.
CAS DataBase Reference
61-25-6(CAS DataBase Reference)
EPA Substance Registry System
Papaverine hydrochloride (61-25-6)
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Safety

Hazard Codes 
Xn,C,F
Risk Statements 
22-34-11
Safety Statements 
22-45-36/37/39-26-16
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
1
RTECS 
NW8575000
8
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29391900
Hazardous Substances Data
61-25-6(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)
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N-Bromosuccinimide Price More Price(8)

Sigma-Aldrich Gold
Product number:
P3510
Product name :
Papaverine hydrochloride
Purity:
powder
Packaging:
5g
Price:
$40.2
Updated:
2019/12/02
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Buy
Sigma-Aldrich Gold
Product number:
1496008
Product name :
Papaverine hydrochloride
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
200mg
Price:
$352.8
Updated:
2019/12/02
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Buy
Alfa Aesar Gold
Product number:
B25412
Product name :
Papaverine hydrochloride, 99%
Packaging:
5g
Price:
$33
Updated:
2020/06/24
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Buy
Alfa Aesar Gold
Product number:
B25412
Product name :
Papaverine hydrochloride, 99%
Packaging:
25g
Price:
$90.4
Updated:
2020/06/24
Buy:
Buy
Sigma-Aldrich Gold
Product number:
P3510
Product name :
Papaverine hydrochloride
Purity:
powder
Packaging:
25g
Price:
$125
Updated:
2019/12/02
Buy:
Buy
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Papaverine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

PAPAVERINE HYDROCHLORIDE is Crystalline Solid

Uses

Smooth muscle relaxant found in opium. Vasodilator (cerebral)

Uses

Vasodilator;Phosphodiesterase inhibitor

Uses

Anti-spasmodic, The treatment of erectile dysfunction

brand name

Pavabid (Hoechst Marion Roussel).

General Description

White powder. pH (0.05 molar solution) 3.9. pH (2% aqueous solution) 3.3.

General Description

Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency.
Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.

Air & Water Reactions

Water soluble.

Reactivity Profile

Papaverine hydrochloride is sensitive to light. .

Health Hazard

SYMPTOMS: Symptoms of exposure to Papaverine hydrochloride may include sleepiness, slowed respiration and slowed heart beat.

Fire Hazard

Flash point data for Papaverine hydrochloride are not available, but Papaverine hydrochloride is probably combustible.

Safety Profile

Poison by ingestion, intraperitoneal, intraduodenal, intravenous, and subcutaneous routes. Human systemic effects: metabolic acidosis, pulse rate increase. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also PAPAVERINE

Purification Methods

Recrystallise it from H2O. It sublimes at 140o/0.1mm. Its solubility in H2O is 5%. [Saunders & Srivastava J Pharm Pharmacol 3 78 1951, Biggs Trans Faraday Soc 50 800 1954.] The free base has m 148-150o, The picrate has m 186-189o(dec, 186-186.5o(dec) [Bobbitt J Org Chem 22 1729 1957]. [Beilstein 21 II 202, 21 III/IV 2788, 21/6 V 182.]

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Global(118)Suppliers
J & K SCIENTIFIC LTD.
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Alfa Aesar
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