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Tylosin Structure

Tylosin

Chemical Properties

Melting point 135-137°C
alpha  D25 -46° (c = 2 in methanol)
Boiling point 796.05°C (rough estimate)
Density  1.1424 (rough estimate)
refractive index  1.5280 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml
form  A crystalline solid
pka pKa 7.73(H2O t = 25 I = 0.167) (Uncertain)
Water Solubility  H2O: soluble 50 mg/mL
Stability Solutions are stable at pH 4-9 (most stable at pH 7);
Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis;
In neutral and alkaline pH – tylosin aldol (TAD) is formed together with polar degradation products of unknown identity;
When tylosin solution is exposed to daylight, a photodegradation product - isotylosin A (isoTA) is formed.
InChIKey WBPYTXDJUQJLPQ-VMXQISHHSA-N
FDA 21 CFR 556.746; 558.625; 558.4
EWG's Food Scores 4
FDA UNII YEF4JXN031
EPA Substance Registry System Tylosin (1401-69-0)

Safety

Symbol(GHS)
Signal wordDanger
Hazard statements H317-H334
Precautionary statements P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes  Xn,N
Risk Statements  42/43-50
Safety Statements  36-61-45-36/37-22
HS Code  2941906000
Hazardous Substances Data 1401-69-0(Hazardous Substances Data)
Toxicity Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.

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Tylosin Chemical Properties,Usage,Production

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