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Idebenone

Product Name:
Idebenone
CAS No.
58186-27-9
Chemical Name:
Idebenone
CBNumber:
CB7733840
Molecular Formula:
C19H30O5
Formula Weight:
338.44
MOL File:
58186-27-9.mol
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Idebenone Property

Melting point:
52-550C
Boiling point:
497.3±45.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
Room temp
pka
15.20±0.10(Predicted)
form 
neat
Merck 
14,4888
InChIKey
JGPMMRGNQUBGND-UHFFFAOYSA-N
CAS DataBase Reference
58186-27-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
WGK Germany 
3
RTECS 
GU5290000
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N-Bromosuccinimide Price More Price(10)

Sigma-Aldrich Gold
Product number:
67805
Product name :
Idebenone
Purity:
analytical standard
Packaging:
10mg
Price:
$70
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
I5659
Product name :
Idebenone
Purity:
≥98% (HPLC)
Packaging:
25mg
Price:
$118
Updated:
2019/12/02
Buy:
Buy
TCI Chemical Gold
Product number:
I0848
Product name :
Idebenone
Purity:
>98.0%(HPLC)(T)
Packaging:
1g
Price:
$88
Updated:
2020/06/24
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Buy
TCI Chemical Gold
Product number:
I0848
Product name :
Idebenone
Purity:
>98.0%(HPLC)(T)
Packaging:
5g
Price:
$262
Updated:
2020/06/24
Buy:
Buy
Cayman Chemical Gold
Product number:
15475
Product name :
Idebenone
Purity:
≥98%
Packaging:
10mg
Price:
$39
Updated:
2020/06/24
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Buy
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Idebenone Chemical Properties,Usage,Production

Description

Idebenone is an organic compound belonging to the quinone family, being similar to coenzyme Q-10. It is a kind of drug developed by Takeda Pharmaceutical Company for the treatment of Alzheimer’s disease and some other cognitive defects. However, these have been not very much progress associated with this indication. It is now also used for the treatment of Friedreich’s ataxia with a positive effect on cardiac hypertrophy and neurological function. However, this indication is only approved in Canada, not in Europe and US. It is now under investigation on its efficacy for the treatment of Duchenne muscular dystrophy, Leber’s hereditary optic neuropathy, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) as well as primary progressive multiple sclerosis. The efficacy of this drug still demands more evidences.

References

https://en.wikipedia.org/wiki/Idebenone
http://www.webmd.com/vitamins-supplements/ingredientmono-1078-idebenone.aspx?activeingredientid=1078&activeingredientname=idebenone

Description

Idebenone is a structural relative of ubiquinone (Coenzyme Q10) that protects the CNS from the effects of ischemia via improving brain metabolism. It is reported to be of potential use in the management of patients with cerebral apoplexy, cerebral arteriosclerosis and related disorders.

Chemical Properties

Yellow-Orange Crystalline Solid

Originator

Takeda (Japan)

Uses

cognition enhancer, nootropic

Uses

chemotherapy drug

Uses

Ubiquinone derivative with protective effects against cerebral ischemia. Nootropic

Uses

idebenone is an anti-oxidant capable of protecting the skin from a variety of free-radical attacks, including the formation of secondary chemicals that negatively affect skin physiology. It is said to improve intrinsic as well as extrinsic skin damage caused by freeradical formation. Idebenone is a synthetically manufactured form of coenzyme Q10 and has a smaller molecular structure. This allows it to penetrate the skin and apparently the cellular membrane. Clinical studies demonstrate a visible improvement in photodamaged skin, reduced skin roughness and dryness, decreased fine lines and wrinkles, and increased skin hydration. In addition, idebenone helps improve hyperpigmentation because its molecular structure is similar to that of hydroquinone. Although most of the associated benefits are seen primarily in the epidermis, some increase in dermal collagen has also been confirmed. Idebenone has been used for such health-related problems as Alzheimer’s and heart disease.

Definition

ChEBI: A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits ere modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.

brand name

AVAN

Biological Activity

Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo . Inhibits apoptosis of astrocytes via increased NGF production.

Idebenone Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Idebenone Suppliers

Global(313)Suppliers
Shaanxi billion Kang Long biological technology co., LTD
Tel:
17791478691
Fax:
4009024560
Email:
997832940@qq.com
Country:
China
ProdList:
296
Advantage:
58
Guangzhou Tonghui Pharmaceutical Co., Ltd.
Tel:
020-66392416
Fax:
020-66392525
Email:
3004254637@qq.com
Country:
China
ProdList:
174
Advantage:
58
Puripharm Co., Ltd.
Tel:
0572-2745768-1;0572-2717806-
Fax:
13167223168
Email:
sales@puripharm.com;yzm@puripharm.com
Country:
China
ProdList:
226
Advantage:
65
Xi'an Kono chem co., Ltd.,
Tel:
029-86107037-8012
Fax:
15691813064
Email:
sales9@konochemical.com
Country:
China
ProdList:
333
Advantage:
58
Shanghai Boyle Chemical Co., Ltd.
Tel:
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax:
+86-21-57758967
Email:
sales@boylechem.com
Country:
China
ProdList:
2214
Advantage:
55
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Fax:
86-21-61259102
Email:
sh@meryer.com
Country:
China
ProdList:
40268
Advantage:
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Fax:
86-21-50328109
Email:
3bsc@sina.com
Country:
China
ProdList:
15880
Advantage:
69
Chembest Research Laboratories Limited
Tel:
021-20908456-
Fax:
021-58180499
Email:
sales@BioChemBest.com
Country:
China
ProdList:
5979
Advantage:
61

58186-27-9, IdebenoneRelated Search:

p-Toluquinone METHOXYBENZOQUINONE 2,3-dimethyl-2,5-cyclohexadiene-1,4 dione 3-methoxy-2,5-toluquinone 2,3-DIMETHOXY-5,6-DIMETHYL-P-BENZOQUINONE Idebenone Methyltriethoxysilane 1,4-Benzoquinone Methyltrimethoxysilane Dimethyldimethoxysilane 1,1-Dimethoxyethane Methyl Methylparaben Kresoxim-methyl Bensulfuron methyl Dimethyl methylphosphonate Methyl acrylate Diphenyldimethoxysilane
  • 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone
  • Avan
  • Daruma
  • Mnesis
  • IDEBENONE(PATENTED-NOSUPPLY)
  • 5,6-Dimethoxy-2-(10-hydroxydecyl)-3-methyl-1,4-benzoquinone
  • 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-5-cyclohexadiene-1,4-dione
  • Idebenone NanoLiposome
  • cv 2619 idebenone
  • 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadienPl,4-dione
  • Daruma:Mnesis
  • 2,5-Cyclohexadiene-1,4-dione, 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-
  • 6-(10-Hydroxydecyl)ubiquinone
  • 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
  • Idebenon
  • 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
  • IDEBENONE(P)
  • Idebenone API
  • Idebenone-d6
  • Idevenone
  • 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylbenzo-1,4-quinone
  • 2,5-Cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-
  • 6-(10-
  • Cerestabon
  • Idebenona [Spanish]
  • Idebenone (JAN)
  • Idebenone whatsapp+86 19930203281
  • aibendikun
  • Idebenone [INN:JAN]
  • Idebenonum [Latin]
  • QSA-10
  • Sovrima
  • Idibenzoquinone
  • debenone
  • 4-dione,5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-5-cyclohexadiene-1
  • 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
  • IDEBENONE
  • cv 2619
  • 2-(10-HYDROXY-DECYL)-5,6-DIMETHOXY-3-METHYL-[1,4]BENZOQUINONE
  • 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
  • idebonone
  • Idebenone98.5%Min
  • 2-(10-Hydroxydecyl)-5,6-methoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
  • Idebenone 58186-27-9
  • Nano Liposomal Idebenone
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  • 58186-27-9
  • Anthraquinones, Hydroquinones and Quinones
  • Cnbio
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • API
  • Other APIs
  • AP
Description References