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Haloperidol

Product Name:
Haloperidol
CAS No.
52-86-8
Chemical Name:
Haloperidol
CBNumber:
CB7774829
Molecular Formula:
C21H23ClFNO2
Formula Weight:
375.86
MOL File:
52-86-8.mol
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Haloperidol Property

Melting point:
152 °C
Boiling point:
529.0±50.0 °C(Predicted)
Density 
1.1820 (estimate)
Flash point:
9℃
storage temp. 
Store at RT
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
pka
8.3(at 25℃)
form 
powder
color 
white
Water Solubility 
2.058mg/L(22.5 ºC)
Merck 
14,4598
CAS DataBase Reference
52-86-8(CAS DataBase Reference)
NIST Chemistry Reference
Haloperidol(52-86-8)
EPA Substance Registry System
Haloperidol (52-86-8)
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Safety

Hazard Codes 
T,F
Risk Statements 
60-61-25-36/37/38-43-39/23/24/25-23/24/25-11
Safety Statements 
53-26-36/37/39-45-36/37-16
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
EU1575000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933399090
Hazardous Substances Data
52-86-8(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington)
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N-Bromosuccinimide Price More Price(14)

Sigma-Aldrich Gold
Product number:
H-030
Product name :
Haloperidol solution
Purity:
1.0mg/mL in methanol, ampule of 1mL, certified reference material
Packaging:
030-1ml
Price:
$26.9
Updated:
2019/12/02
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Sigma-Aldrich Gold
Product number:
1303002
Product name :
Haloperidol
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
200mg
Price:
$352.8
Updated:
2019/12/02
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TCI Chemical Gold
Product number:
H0912
Product name :
Haloperidol
Purity:
>98.0%(HPLC)(T)
Packaging:
5g
Price:
$73
Updated:
2020/06/24
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TCI Chemical Gold
Product number:
H0912
Product name :
Haloperidol
Purity:
>98.0%(HPLC)(T)
Packaging:
25g
Price:
$216
Updated:
2020/06/24
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Alfa Aesar Gold
Product number:
J61688
Product name :
Haloperidol
Packaging:
5g
Price:
$75.8
Updated:
2020/06/24
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Haloperidol Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Powder

Uses

Antidyskinetic; antipsychotic

Definition

ChEBI: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

brand name

Haldol (OrthoMcNeil).

General Description

Haloperidol, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4-fluorobutyrophenone (Haldol), is anodorless white to yellow crystalline powder. Haloperidol iswell and rapidly absorbed and has a high bioavailability. It ismore than 90% bound to plasma proteins. Haloperidol is excretedslowly in the urine and feces. About 30% of a dose isexcreted in urine and about 20% of a dose in feces via biliaryelimination,and only 1% of a dose is excreted as unchangeddrug in the urine.Haloperidol is a minor substrate of CYP1A2 and a major substrate of CYP2D6 and CYP3A4.CYP2D6 inhibitors may increase the levels/effects ofhaloperidol.Haloperidol may increase the levels/effects ofCYP2D6 substrates and it may decrease the bioactivationof CYP2D6 prodrugs substrates. Haloperidol also is a moderateinhibitor of CYP2D6 and CYP3A4. CYP3A4 inducersmay decrease the levels/effects of haloperidol, whereasCYP3A4 inhibitors may increase the levels/effects ofhaloperidol. Centrally acting acetylcholinesterase inhibitorsmay increase the risk of antipsychotic-related EPS. The precisemechanism of antipsychotic action is unclear but isconsidered to be associated with the potent DA D2receptor–blocking activity in the mesolimbic system and theresulting adaptive changes in the brain. Haloperidol is usedprimarily for the long-term treatment of psychosis and is especiallyuseful in patients who are noncompliant with theirdrug treatment.

General Description

Haloperidol, 4[4-(p-chlorophenyl)-4-hydroxypiperidone]-4' -n-fluorobutyrophenone (Haldol),the representative of several related classes of aromaticbutylpiperidine derivatives, is a potent antipsychotic usefulin schizophrenia and in psychoses associated with braindamage. It is frequently chosen as the agent to terminatemania and often used in therapy for Gilles de la Tourettesyndrome. Haloperidol-induced dyskinesias may involveneurotoxicological metabolite similar to dopaminergic toxicantMPP+.

Pharmaceutical Applications

Haloperidol is an analogue of the dopamine D2 receptor antagonist and is an older antipsychotic drug. The drug is used in the treatment of schizophrenia, a neuropsychiatric disorder. In general, antipsychotic drugs work by blocking the dopamine D2 receptors.
Haloperidol is such an antipsychotic drug, which was developed in the 1950s and entered the clinic soon after that. Its use is limited by the high incidence of extrapyramidal symptoms (movement disorders caused by drugs affecting the extrapyramidal system, a neural network which is part of the motor system). Nevertheless, haloperidol may be used for the rapid control of hyperactive psychotic states and is popular for treating restlessness in the elderly.

Biological Activity

Dopamine antagonist with selectivity for D 2 -like receptors (K i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). Subtype-selective NMDA antagonist.

Haloperidol Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Haloperidol Suppliers

Global(164)Suppliers
J & K SCIENTIFIC LTD.
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TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
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021-67121385
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Sales-CN@TCIchemicals.com
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Energy Chemical
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52-86-8, HaloperidolRelated Search:

HALOPERIDOL RELATED COMPOUND A 4,4-BIS[4-P-CHLOROPHENYL)-4-HYDROXY-PIPERIDINO]BUTYROPHENONE USP(CRM STANDARD) IOHEXOL IMPURITY J HALOPERIDOL ASSAY STANDARD BP(CRM STANDARD) IOHEXOL IMPURITY A haloperidol hemisuccinate HALOPERIDOL, TG CONJUGATE clofluperol HALOPERIDOL-D4,100/MLINMETHANOL,HALOPERIDOL-D4 HALOPERIDOL HYDROCHLORIDE HALOPERIDOL, [3H(G)]- TriphenylMethyl chloride Haloperidol caprate Chlorodimethylphenylsilane Diphenoxylate 2-Butanone tert-Butylchlorodiphenylsilane CHLOROPHOSPHONAZO III Haloperidol
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