ChemicalBook > CAS DataBase List > Calcium acetate

Calcium acetate

Product Name:
Calcium acetate
CAS No.
62-54-4
Chemical Name:
Calcium acetate
CBNumber:
CB8312095
Molecular Formula:
C4H6CaO4
Formula Weight:
158.17
MOL File:
62-54-4.mol
More
Less

Calcium acetate Property

Melting point:
160°C (dec.)
Density 
1,5 g/cm3
FEMA 
2228 | CALCIUM ACETATE
refractive index 
1.5500
Flash point:
160°C
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Powder
color 
white
Specific Gravity
1.50
Water Solubility 
soluble
Decomposition 
160 ºC
Stability:
Stable. Non-flammable. Incompatible with strong oxidizing agents.
InChIKey
VSGNNIFQASZAOI-UHFFFAOYSA-L
CAS DataBase Reference
62-54-4(CAS DataBase Reference)
EPA Substance Registry System
Calcium acetate (62-54-4)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
RTECS 
AF7525000
TSCA 
Yes
HS Code 
29152990
Hazardous Substances Data
62-54-4(Hazardous Substances Data)
More
Less

N-Bromosuccinimide Price More Price(5)

Sigma-Aldrich Gold
Product number:
PHR1362
Product name :
Calcium Acetate
Purity:
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging:
5g
Price:
$31.1
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
1086334
Product name :
Calcium Acetate
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
1g
Price:
$348
Updated:
2018/11/13
Buy:
Buy
Strem Chemicals Gold
Product number:
93-2001
Product name :
Calcium acetate monohydrate, 98%
Packaging:
250g
Price:
$50
Updated:
2020/06/24
Buy:
Buy
Strem Chemicals Gold
Product number:
93-2001
Product name :
Calcium acetate monohydrate, 98%
Packaging:
1kg
Price:
$150
Updated:
2020/06/24
Buy:
Buy
Sigma-Aldrich Gold
Product number:
1086334
Product name :
Calcium acetate
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
500mg
Price:
$352.8
Updated:
2019/12/02
Buy:
Buy
More
Less

Calcium acetate Chemical Properties,Usage,Production

Chemical properties

Calcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It is an odorless powder. Calcium has an important role in the nutrition of humans and animals. Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL. Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.*

Uses

Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. It is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life.

Toxicity

ADI is not subject to restrictive regulations (FAO/WHO, 2001).
GRAS (FDA, §181.29, §182.6197, § 184.1185, 2000).
LD50: 52 mg/kg (mouse, subcutaneous).

Usage limit

GB 14880 a 94: cereals and their products, beverages 8~16g/kg.
GB 2760-2001: vinegar, 6~8g/kg (in terms of Ca).
FAO/WHO (1984): Edible caseinate, GMP.
FDA, § 184.1185 (2000): baked goods, gelatin, pudding, fillings, 0.2%; sweet sauce, top materials and poured, 0.15%;
EEC can be used for packaging cheese powder, quick-setting jelly powder.
FEMA (mg/kg): soft drinks 200; baked goods 500.

Production method

It is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate.
It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization.
It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt.
Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%.
To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated  80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.

Hazards & Safety Information

Category:  Toxic substances
Toxicity classification:  highly toxic
Acute toxicity:  intravenous-mouse LD50: 52 mg/kg; celiac-mouse LD50: 75 mg/kg
Flammability and Hazardous characteristics:  Thermal decomposition releases Pungent irritation Smoke
Storage and transportation characteristics:Treasury: ventilated, low temperature drying; store it separately from food raw materials
Fire extinguishing agent:  water, dry powder, foam, carbon dioxide

Description

Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.

Chemical Properties

Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.

Uses

Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.

Uses

Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.

Definition

ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.

Production Methods

Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

Preparation

Produced by calcium hydroxide neutralization of acetic acid.

Pharmaceutical Applications

Calcium acetate is used as a preservative in oral and topical formulations.
Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes.

Safety

Calcium acetate is used in oral and topical formulations. The pure form of calcium acetate is toxic by IP and IV routes.
LD50 (mouse, IP): 0.075 g/kg
LD50 (mouse, IV): 0.052 g/kg
LD50 (rat, oral): 4.28 g/kg

Veterinary Drugs and Treatments

Calcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption.

storage

Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.

Purification Methods

Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]

Incompatibilities

Calcium acetate is incompatible with strong oxidizing agents and moisture.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.

Less

Calcium acetate Suppliers

Global(260)Suppliers
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Fax:
86-21-61259102
Email:
sh@meryer.com
Country:
China
ProdList:
40268
Advantage:
62
Beijing Ouhe Technology Co., Ltd
Tel:
010-82967028-
Fax:
+86-10-82967029
Email:
2355560935@qq.com
Country:
China
ProdList:
12365
Advantage:
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel:
13817811078,021-50426030
Fax:
86-021-50426522,50426273
Email:
sales@jingyan-chemical.com
Country:
China
ProdList:
10009
Advantage:
60
Adamas Reagent, Ltd.
Tel:
400-600-9262
Email:
bxy@titansci.com
Country:
China
ProdList:
13918
Advantage:
59
Nanjing MeiBo Biological Technology Co., Ltd.
Tel:
025-58619198
Fax:
025-58619197
Email:
sales@mbbio.com
Country:
China
ProdList:
319
Advantage:
60
Tianjin heowns Biochemical Technology Co., Ltd.
Tel:
400 638 7771
Email:
sales@heowns.com
Country:
China
ProdList:
14460
Advantage:
57
Sinopharm Chemical Reagent Co,Ltd.
Tel:
86-21-63210123
Fax:
86-21-63290778 86-21-63218885
Email:
sj_scrc@sinopharm.com
Country:
China
ProdList:
9848
Advantage:
79
Spectrum Chemical Manufacturing Corp.
Tel:
021-67601398-809
Fax:
021-57711696
Email:
marketing_china@spectrumchemical.com;
Country:
China
ProdList:
9688
Advantage:
60

62-54-4, Calcium acetateRelated Search:

FUMARIC ACID MONOETHYL ESTER, CALCIUM SALT 2'-CALCIUM CITRATE Ketoleucine calcium salt dihydrate CALCIUM L-ARABONATE D-(+)-Pantothenic acid calcium salt Calcium L-lactate 2-KETO-D-GLUCONIC ACID HEMICALCIUM SALT Calcium folinate Pyruvic Acid Calcium Salt Calcium stearate 4-CHLOROBENZOYL-L-TRYPTOPHAN CALCIUM SALT calcium benzamidosalicylate Calcium phenylpyruvate Calcium Propionate CALCIUM OROTATE DL-GLYCERIC ACID HEMICALCIUM SALT HYDRATE Calcium 2-ethylhexanoate 3-METHYL-2-OXOPENTANOIC ACID CALCIUM
  • acetatedecalcium
  • Aceticacid,calciunsalt
  • teltozan
  • vinegarsalts
  • CALCIUM ACETATE EXTRA PURE, FCC, E 263
  • CALCIUM ACETATE HYDRATE PURE
  • CALCIUM ACETATE HYDRATE, 99.99%
  • CALCIUM ACETATE SIGMAULTRA
  • CALCIUM ACETATE SOLUTION
  • CALCIUM ACETATE 99.999%
  • CALCIUM ACETATE HYDRATE, REAGENTPLUS TM >= 99%
  • CALCIUM ACETATE HYDRATE, POWDER
  • CalciumAcetateFcc
  • CalciumAcetateBp
  • CalciumAcetateDried(ForSoilTest)
  • FEMA 2228
  • CALCIUM ACETATE
  • Calcium acetate - dried
  • CALCIUM DIACETATE
  • MAGNESIA 87219
  • MAGGRAN(R) CA
  • ACETIC ACID, CALCIUM SALT
  • CALCIUM ACETATE PWD
  • brownacetate
  • brownacetateoflime[qr]
  • grayacetate
  • grayacetateoflime[qr]
  • limeacetate
  • limepyrolignite
  • sorbo-calcion
  • CalciumAcetateGr
  • CalciumAcetateUsp
  • CalciumAcetate,>98%
  • Calcium acetate hydrate, Puratronic, 99.9965% (metals basis)
  • Calciumacetatemonohydrate,98%
  • CALCIUMACETATE,POWDER,FCC
  • CALCIUMACETATE,POWDER,FCC(BULK
  • CALCIUM(II)ACETATE
  • Calciumacetat
  • CALCIUM ACETATE POWDER
  • Calciumacetatehydrate,97%
  • CALCIUM ACETATE 1-HYDRATE
  • Brown acetate of lime
  • Gray acetate of lime
  • Di(acetic acid)calcium
  • Calcium acetate hydrate, Puratronic
  • Calcium acetate ,99%
  • Acetic acid, calciuMsalt (2:1)
  • Calcium Acetate (1 g) (AS)
  • 62-54-4
  • 32-54-4
  • 11460-21-8
  • CH3COO2Ca
  • C4H6O4CaH2O
  • CH3CO22Ca
  • CaOOCCH32H2O
  • C4CaH6O4
  • CaOOCCH32稨2O
Chemical properties Uses Toxicity Usage limit Production method Hazards & Safety Information