Chemical Properties
white to very pale yellow crystals or
Uses
4-(Trifluoromethyl)benzeneacetic Acid is an intermediate used to synthesize PPARγ/δ dual agonists via solid-Phase parallel synthesis. It was also used to prepare heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
General Description
4-(Trifluoromethyl)phenylacetic acid undergoes diolefination mediated by mono-
N-protected amino acid ligands in the presence of ethyl acrylate, Pd(OAc)
2, KHCO
3 and
t-amyl alcohol.
