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2'-Hydroxyacetophenone

Product Name:
2'-Hydroxyacetophenone
CAS No.
118-93-4
Chemical Name:
2'-Hydroxyacetophenone
CBNumber:
CB8421762
Molecular Formula:
C8H8O2
Formula Weight:
136.15
MOL File:
118-93-4.mol
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2'-Hydroxyacetophenone Property

Melting point:
3-6 °C(lit.)
Boiling point:
213 °C717 mm Hg(lit.)
Density 
1.131 g/mL at 25 °C(lit.)
vapor density 
4.7 (vs air)
vapor pressure 
~0.2 mm Hg ( 20 °C)
FEMA 
3548 | 2-HYDROXYACETOPHENONE
refractive index 
n20/D 1.558(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
0.2g/l
pka
10.06(at 25℃)
form 
Liquid
color 
Clear yellow to brown
explosive limit
0.98-11.8%(V)
Water Solubility 
slightly soluble
JECFA Number
727
BRN 
386123
CAS DataBase Reference
118-93-4(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(2-hydroxyphenyl)-(118-93-4)
EPA Substance Registry System
2'-Hydroxyacetophenone (118-93-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
AM8575000
8
Hazard Note 
Harmful/Irritant
TSCA 
Yes
HS Code 
29145000
Toxicity
LD50 orally in Rabbit: 2127 mg/kg LD50 dermal Rat > 2000 mg/kg
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N-Bromosuccinimide Price More Price(14)

Sigma-Aldrich Gold
Product number:
H18607
Product name :
2′-Hydroxyacetophenone
Purity:
ReagentPlus , 99%
Packaging:
5g
Price:
$20.3
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
18245
Product name :
2′-Hydroxyacetophenone
Purity:
analytical standard
Packaging:
1ml
Price:
$60.5
Updated:
2019/12/02
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Buy
TCI Chemical Gold
Product number:
H0192
Product name :
2'-Hydroxyacetophenone
Purity:
>98.0%(HPLC)(T)
Packaging:
25g
Price:
$16
Updated:
2020/06/24
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Buy
TCI Chemical Gold
Product number:
H0192
Product name :
2'-Hydroxyacetophenone
Purity:
>98.0%(HPLC)(T)
Packaging:
100g
Price:
$34
Updated:
2020/06/24
Buy:
Buy
Alfa Aesar Gold
Product number:
A12550
Product name :
2'-Hydroxyacetophenone, 98%
Packaging:
100g
Price:
$21.5
Updated:
2020/06/24
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2'-Hydroxyacetophenone Chemical Properties,Usage,Production

Description

It is a typical flavour additive for cherry kernel, cinnamon, rum, tobacco, coumarin, and tropical fruit. Moreover, it can be used as the intermediate or raw material in organic synthesis. Specifically, this chemical may act as the raw material to prepare a Schiff’s base al-alkoxide initiator that facilitates the controlled polymerization of DL-lactide.1 This substance can also function as the effective component in balsamic compounds for fabricating taste modifying compositions.2 Additionally, this chemical has been employed to react with benzoyl chloride for generating 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran, which exhibits good performance for treating cancer and other proliferative diseases such as psoriasis and restenosis.3

Reference

  1. Bhaw-Luximon, A.; Jhurry, D.; Spassky, N., Controlled polymerization of DL-lactide using a Schiff's base al-alkoxide initiator derived from 2-hydroxyacetophenone. Polym. Bull. 2000, 44, 31-38.
  2. Johann Wonschick; Clemens M. Putter; Keepe, E., TASTE MODIFYING COMPOSITIONS PCT WO 2016/103183 A1 2016.
  3. Alexander J Bridges; Saltiel, A. R., 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders US Patent US5525625 1996.

Chemical Properties

clear yellow to brown liquid

Chemical Properties

2-Hydroxyacetophenone has a sweet, heavy floral, herbaceous odor, reminiscent of mown hay or hawthorn

Occurrence

Reported found in beef, cassia oil, cocoa, cocoa powder, coffee, Jamaican rum, tomato, Scotch whiskey, sherry, tea, mountain papaya, papaya, roasted almond and black choke berry

Uses

2’Hydroxyacetophenone is a phenolic compound used in the synthesis of potential anti-myobacterial and anticancer agents.

Preparation

Preparation by Fries rearrangement of phenyl acetate, with Lewis acids
aluminium chloride.

Aroma threshold values

Detection: 5.5 ppm; aroma characteristics at 2.0%: phenolic, sharp, benzaldehyde, cherry pit, tropical, melon with a tobacco afternote

Taste threshold values

Taste characteristics at 5.0 ppm: naphthyl, cinnamon, cherry pit, coumarin, phenolic, tobacco and honey.

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2'-Hydroxyacetophenone Suppliers

Global(406)Suppliers
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel:
0536-2101172- ;
Fax:
0536-2101172
Email:
sdfantai@163.com;sdfantai@163.com
Country:
China
ProdList:
530
Advantage:
58
Weifang Qianyuan Biotechnology Co., Ltd.
Tel:
Email:
1297429207@qq.com
Country:
China
ProdList:
91
Advantage:
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel:
022-66880623;022-89880623
Fax:
86(0)22-66880086
Email:
sales@tjzxchem.com;sales@tjzxchem.com
Country:
China
ProdList:
582
Advantage:
60
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Fax:
86-21-61259102
Email:
sh@meryer.com
Country:
China
ProdList:
40268
Advantage:
62
INTATRADE GmbH
Tel:
+49 3493/605464
Fax:
+49 3493/605470
Email:
sales@intatrade.de
Country:
Germany
ProdList:
3579
Advantage:
66
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Fax:
021-67582001/03/05
Email:
saleschina@alfa-asia.com
Country:
China
ProdList:
30163
Advantage:
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TAIYUAN RHF CO.,LTD.
Tel:
+86 351 7031519
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+86 351 7031519
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sales@RHFChem.com
Country:
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TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Fax:
021-67121385
Email:
Sales-CN@TCIchemicals.com
Country:
China
ProdList:
24555
Advantage:
81

118-93-4, 2'-HydroxyacetophenoneRelated Search:

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  • Pharmaceutical intermediates for Choleretic and Salbutamol
Description Reference