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Hexachlorophene

Product Name:
Hexachlorophene
CAS No.
70-30-4
Chemical Name:
Hexachlorophene
CBNumber:
CB8687902
Molecular Formula:
C13H6Cl6O2
Formula Weight:
406.9
MOL File:
70-30-4.mol
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Hexachlorophene Property

Melting point:
163-165 °C(lit.)
Boiling point:
519.9°C (rough estimate)
Density 
1.6065 (rough estimate)
refractive index 
1.5550 (estimate)
Flash point:
11 °C
storage temp. 
2-8°C
pka
pKa 4.89 ± 0.02(H2O,t = 25.0±0.1,I=0.1(NaCl)) (Uncertain)
form 
crystalline
color 
off-white to tan
Water Solubility 
19mg/L(25 ºC)
λmax
300nm(MeOH)(lit.)
Merck 
14,4680
BRN 
2064407
Stability:
Stable. Incompatible with alkalies, akaline earths, tweens, strong oxidizers.
CAS DataBase Reference
70-30-4(CAS DataBase Reference)
NIST Chemistry Reference
2,2'-Methylenebis(3,4,6-trichlorophenol)(70-30-4)
EPA Substance Registry System
Hexachlorophene (70-30-4)
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Safety

Hazard Codes 
T,N,F
Risk Statements 
24/25-50/53-52/53-39/23/24/25-23/24/25-11-51/53
Safety Statements 
20-37-45-60-61-36/37-16
RIDADR 
UN 2875 6.1/PG 3
WGK Germany 
3
RTECS 
SM0700000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29072990
Hazardous Substances Data
70-30-4(Hazardous Substances Data)
Toxicity
LD50 in adult male, female rats (mg/kg): 66, 57 orally (Gaines, Linder)
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N-Bromosuccinimide Price More Price(7)

Sigma-Aldrich Gold
Product number:
45526
Product name :
Hexachlorophene
Purity:
PESTANAL
Packaging:
250mg
Price:
$41.6
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
1305008
Product name :
Hexachlorophene
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
500mg
Price:
$338.1
Updated:
2019/12/02
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Buy
Cayman Chemical Gold
Product number:
23948
Product name :
Hexachlorophene
Purity:
≥98%
Packaging:
500mg
Price:
$25
Updated:
2018/11/19
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Buy
Cayman Chemical Gold
Product number:
23948
Product name :
Hexachlorophene
Purity:
≥98%
Packaging:
1g
Price:
$48
Updated:
2018/11/19
Buy:
Buy
Sigma-Aldrich Gold
Product number:
40323
Product name :
Hexachlorophene solution
Purity:
certified reference material, 5000 μg/mL in methanol
Packaging:
40323
Price:
$45
Updated:
2019/12/02
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Buy
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Hexachlorophene Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Solid

Chemical Properties

Hexachlorophene is a crystalline solid com pound.

Uses

Hexachlorophene is a topical antiseptic in germicidal soaps, creams, deodorants, cleansers, shampoos, after-shave creams, pHisoHex surgical cleanser and in veterinary medicine.

Uses

Used as an antiseptic

Uses

antiinfective (topical)

Definition

ChEBI: An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.

brand name

Dial (Dial); E-Z Scrub (Becton Dickinson Microbiology); Gamophen (Arabrook); Germa-Medica (Huntington); Hexa-Germ (Huntington); Hexascrub (Prof Dspls); Phiso-Scrub (Sanofi Aventis); Phisohex (Sanofi Aventis); Pre-Op (Davis & Geck); Septi-Soft (Calgon); Septisol (Vestal); Soy-Dome (Bayer); Turgex (Xttrium);99 armour formula;Acnestrol (broparestrol);Acnestrol 3;Akne pyodron kur;Aknefug;Aknelan;Anacal;Asecool;Aserbine cream;Bilvon vet;Bismodyne;Cinthol;Clenisep;Coopaphene;Cordocel-h;Cresophene;Delta pimafucort;Derivative;Derl;Derma 10;Derma leaf;Dermohex;Dermolle;Dexolan;Dial toilet soap;Distocid;Dk 2;Dovaso;Ecto pellicur;Ectofum;Emlab;Fisohen;Fisohexx;Fitty derm;Flenaphthol;Gamophen surgical soap;Germibon;Gill soap;Haemovin;Heksaden;Hepadist;Hexadespon;Hexal;Hexaphenyl(1&b);Hexocreme;Hex-o-san;Jabon antiseptico;Kalacid;Lf 530;Loftyzon;Mamex;Mantacido;Med liquide san t;Micogamma;Nestosyl;P 47;Paradentol;Permucal;Phaisohex;Phasca;Phiso scrub;Phisohex(winthrop);Phiso-med;Phisoscrub;Phlebodine;Phorac;Phosohex;Predekzem;Pretulon;Proct anex;Prodermopur;Sapo-chlor;Sapoderm;Sebbafon;Sebo-cds;Sergi-cen;Skrub kreme;Solu-heks;Steridermis washing cream;Ster-zac antibacterial shaving foam;Ster-zac antibacterial soap;Ster-zac dc skin cleanser;Ster-zac powder;Sumasept;Super sat;Surg salve;Surge vet;Toracsol;Torbetol lotion;Vanseb;Vetalderm;Vulnusol spray;Wesco hex;Wescohex;Westasept;Zalpon antibacterial washing cream.

World Health Organization (WHO)

Hexachlorophene, an antimicrobial agent, was introduced in 1948 in proprietary liquid preparations and powders and was subsequently used extensively as a topical antiseptic. By the early 1970s its use in infants had been conclusively demonstrated to cause encephalopathy as a result of transdermal absorption. More recently it has been suggested that the drug has a teratogenic potential. Many regulatory authorities have placed rigorous restrictions on the medicinal use of hexachlorophene, particularly in preparations intended for infants. However, its use still commonly remains permissible at low concentrations as a preservative in toiletries and cosmetics. (Reference: (WHODI) WHO Drug Information, 3, 6, 1978)

General Description

A white free-flowing odorless powder. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Hexachlorophene is incompatible with strong oxidizers. Hexachlorophene forms salts with alkalis and alkaline earths.

Hazard

FDA prohibits use unless prescribed by a physician. Questionable carcinogen.

Health Hazard

Inhalation of dust is poisonous; irritating to mucous membranes. Eye and skin irritant. Poisonous if swallowed. Symptoms following ingestion include anorexia, nausea, vomiting, abdominal cramps, and diarrhea. Dehydration may be severe and may be associated with shock.

Potential Exposure

HCP has been used as an antibacterial agent in a wide variety of consumer products, including soaps and deodorants; as a disinfectant. It has also been used as an antifungal agent to treat various citrus fruits and vegetables.

Shipping

UN2875 Hexachlorophene, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It forms needles from MeOH, C2H4Cl2, or toluene. The diacetate has m 175-176o (EtOH). A disinfectant is also available in MeOH (5mg/L). [Beilstein 6 III 5407, 6 IV 6659.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste con taining this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treat ment, and waste disposal.

Hexachlorophene Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Hexachlorophene Suppliers

Global(94)Suppliers
SHANGHAI SINOCHEMTECH CO.,LTD.
Tel:
86-21-37788339,50185998/17721086216
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86-21-5768-0031
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Shanghai eliv pharmaceutical Co.,Ltd.
Tel:
021-50158063
Fax:
(86)21-6153 1846
Email:
sales@elivpharma.com
Country:
China
ProdList:
919
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Shanghai Boyle Chemical Co., Ltd.
Fax:
86-21-57758967
Email:
sales@boylechem.com
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2926
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J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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Beckmann-Kenko GmbH
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+49 4241 9308 88
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+49 4241 9308 89
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Germany
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199
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Syntechem Co.,Ltd
Tel:
Please Email
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E-Mail Inquiry
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