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Propylene carbonate

Product Name:
Propylene carbonate
CAS No.
108-32-7
Chemical Name:
Propylene carbonate
CBNumber:
CB8852744
Molecular Formula:
C4H6O3
Formula Weight:
102.08864
MOL File:
108-32-7.mol
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Propylene carbonate Property

Melting point:
-49 °C
Boiling point:
240 °C(lit.)
Density 
1.204
vapor pressure 
0.13 mm Hg ( 20 °C)
refractive index 
n20/D 1.421(lit.)
Flash point:
270 °F
storage temp. 
Store below +30°C.
solubility 
240g/l
form 
Liquid
Specific Gravity
1.209 (20/4℃)
color 
Clear
Relative polarity
6
PH
7.0 (200g/l, H2O, 20℃)
explosive limit
1.8-14.3%(V)
Water Solubility 
240 g/L (20 ºC)
λmax
λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01
BRN 
107913
Stability:
Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water.
InChIKey
RUOJZAUFBMNUDX-UHFFFAOYSA-N
CAS DataBase Reference
108-32-7(CAS DataBase Reference)
NIST Chemistry Reference
Propylene carbonate(108-32-7)
EPA Substance Registry System
Propylene carbonate (108-32-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26-37/39
WGK Germany 
1
RTECS 
FF9650000
3-10
Autoignition Temperature
851 °F
TSCA 
Yes
HS Code 
29209010
Hazardous Substances Data
108-32-7(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 20000 mg/kg
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N-Bromosuccinimide Price More Price(24)

Sigma-Aldrich Gold
Product number:
310328
Product name :
Propylene carbonate
Purity:
anhydrous, 99.7%
Packaging:
1l
Price:
$120
Updated:
2019/12/02
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Sigma-Aldrich Gold
Product number:
1576504
Product name :
Propylene carbonate
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
200mg
Price:
$384.65
Updated:
2019/12/02
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TCI Chemical Gold
Product number:
P0525
Product name :
Propylene Carbonate
Purity:
>98.0%(GC)
Packaging:
25g
Price:
$17
Updated:
2020/06/24
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TCI Chemical Gold
Product number:
P0525
Product name :
Propylene Carbonate
Purity:
>98.0%(GC)
Packaging:
500g
Price:
$35
Updated:
2020/06/24
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Alfa Aesar Gold
Product number:
A15552
Product name :
Propylene carbonate, 99%
Packaging:
1000g
Price:
$44.8
Updated:
2020/06/24
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Propylene carbonate Chemical Properties,Usage,Production

Propylene Carbonate as Solvent

In the context of Green Chemistry, processes that minimise environmental impact are of great interest at both the industrial and academic levels, and the use of solvents that are innocuous to the environment is also a factor of great interest. Propylene carbonate maybe an appropriate choice. Not only it has a low evaporation rate, low toxicity, and VOC exemption, PC also has other benefits such as:

  • Improves lubricity
  • It is chemically stable
  • Co-firing in any atmosphere without oxidation
  • Excellent viscosity properties and green strength
  • Propylene Carbonate is one of the most eco-efficient alternatives for coating wires

Chemical Properties

colourless liquid

Chemical Properties

Propylene carbonate is a clear, colorless, mobile liquid, with a faint odor.

Uses

Pharmaceutic aid (gelling agent).

Uses

propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent.

Production Methods

Propylene carbonate may be prepared by the reaction of sodium bicarbonate with propylene chlorohydrin.

Preparation

To a stirred solution of 1,2- propanediol 957 (230 mg, 3.0 mmol) in toluene (8 mL) was added DPC (670 mg, 3.1 mmol). After stirring at 110 ℃ for 1.5 h, the reaction mixture was allowed to cool to room temperature, diluted with dichloromethane (40 mL), washed with brine (30 mL), dried over anhydrous MgSO4, and concentrated to dryness under reduced pressure. The crude product was distilled in vacuo in a kugelrohr apparatus to give 4-methyl-1,3-dioxolan-2-one 958 (254 mg) in 83% yield.

Pharmaceutical Applications

Propylene carbonate is used mainly as a solvent in oral and topical pharmaceutical formulations.
In topical applications, propylene carbonate has been used in combination with propylene glycol as a solvent for corticosteroids. The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene carbonate has been used as a dispensing solvent in topical preparations.
Propylene carbonate has also been used in hard gelatin capsules as a nonvolatile, stabilizing, liquid carrier. For formulations with a low dosage of active drug, a uniform drug content may be obtained by dissolving the drug in propylene carbonate and then spraying this solution on to a solid carrier such as compressible sugar; the sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at room and elevated temperatures, for many cellulose-based polymers and plasticizers. Propylene carbonate is also used in cosmetics.

Safety

Propylene carbonate is used as a solvent in oral and topical pharmaceutical formulations, and is generally regarded as an essentially nontoxic and nonirritant material.
In animal studies, propylene carbonate was found to cause tissue necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg

storage

Propylene carbonate and its aqueous solutions are stable but may degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place.

Purification Methods

It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.]

Incompatibilities

Propylene carbonate hydrolyzes rapidly in the presence of strong acids and bases, forming mainly propylene oxide and carbon dioxide. Propylene carbonate can also react with primary and secondary amines to yield carbamates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical ointments). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Propylene carbonate Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Propylene carbonate Suppliers

Global(323)Suppliers
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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TCI (Shanghai) Development Co., Ltd.
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JOBACHEM Trading (Suzhou) Co.,Ltd.
Tel:
0512-62927368-
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Tianjin Zhongxin Chemtech Co., Ltd.
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future industrial shanghai co., ltd
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Alfa Aesar
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021-67582001/03/05
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  • 4-Methyl-2-oxo-1,3-dioxolane
  • 4-methyl-3-dioxolan-2-one
  • 4-Methyldioxalone-2
  • Arconate propylene carbonate
  • arconate5000
  • carbonatedepropylene
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Propylene Carbonate as Solvent